Cloned (Comment) | Organism |
---|---|
DNMT2 controls retrotransposon silencing and 2R and 3R telomere integrity in somatic cells, overview | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of a series of null mutations by remobilization of the EP(2)GE15695 element inserted 108 bp upstream of the Dnmt2 gene. EP(2)GE15695 does not affect the Dnmt2 gene. Dnmt2 null strains show stable loss of the subtelomeric clusters of defective Invader4 elements, phenotype, overview | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Drosophila melanogaster | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | early embryogenesis | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | - |
Drosophila melanogaster | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytosine-5 methyltransferase | - |
Drosophila melanogaster |
Dnmt2 | - |
Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | DNMT2 controls retrotransposon silencing and telomere integrity in somatic cells, significant DNMT2-dependent DNA methylation occurs during early embryogenesis, overview | Drosophila melanogaster |