EC Number   |
General Information |
Reference |
|---|
    1.4.3.2 | evolution |
enzyme is placed within the clade of homologous proteins from elapid snakes, characterized by the conserved serine at position 223 |
763542 |
| 1.4.3.2 | evolution |
the enzyme is evolutively close related to LAAOs from Bothrops jararacussu, Bothrops moojeni and Bothrops atrox, and together with the LAAO from Bothrops pauloensis, they form a well-defined cluster of the Bothrops genus |
763758 |
| 1.4.3.2 | more |
crude recombinant LAAO enzyme displays strong antibacterial activity against aquatic pathogens, particularly Streptococcus agalactiae and Streptococcus iniae. The antibacterial activity of recombinant LAAO is directly associated with H2O2 production, the crude enzyme can maintain a high level of antibacterial activity against both Gram-positive and -negative bacteria from 4°C to 30°C |
763048 |
| 1.4.3.2 | more |
enzyme blocks aggregation induced by collagen on washed blood platelets in a rather weak manner, it does not inhibit platelet aggregation induced by ADP on platelet-rich plasma. The enzyme displays in vitro antibacterial activity against Staphylococcus aureus (MIC/MBC of 0.39 microg/ml) and in vitro leishmanicidal action against Leishmania amazonensis and L. chagasi (IC50 values of 0.14 and 0.039 microg/ml, respectively). These activities are significantly reduced by catalase |
763143 |
| 1.4.3.2 | more |
screening of L-amino acid oxidase activities in higher fungi using crude aqueous extracts of fruiting bodies of 22 basidiomycetes and 1 ascomycete. Half of these samples exhibit one to two bands of LAO activities with mostly broad substrate specificities and a variety of apparent molecular masses ranging from 25 to 200 kDa that are generally more active at pH 5.5 than at pH 8.0 |
762526 |
| 1.4.3.2 | more |
the enzyme induces edema in mice, inhibits human platelet aggregation induced by ADP in a dose-dependent manner and shows antibacterial activity on Gram-positive and Gram-negative bacteria |
763758 |
| 1.4.3.2 | more |
toxophallin is a highly cytotoxic protein, but differs distinctly from the other death cap toxic protein phallolysin. The interaction of toxophallin with target cells is not mediated by a specific cell surface receptor |
711980 |
| 1.4.3.2 | physiological function |
a deaminase-deficient mutant is not viable |
-, 740597 |
| 1.4.3.2 | physiological function |
Akbu-LAAO shows apparent anti-aggregation effects on human and rabbit platelets and exhibits a strong bacteriostasis effect on Staphylococcus aureus, 18fold that of cephalosporin C |
711329 |
| 1.4.3.2 | physiological function |
compared to wild-type mice, LAO1 KO mice exhibit impaired fear learning and memory function in a passive avoidance test, coinciding with significantly reduced hippocampal acetylcholine levels, while treatment with donepezil, a reversible acetylcholine esterase inhibitor, inhibits this reduction. Knocking out LAO1 affects amino acid metabolism (mainly of phenylalanine) in the hippocampus. Phenylalanine levels are elevated in LAO1 KO mice, while phenylpyruvic acid levels are reduced. Knocking out LAO1 decreases hippocampal mRNA levels of pyruvate kinase, which is inhibited by phenylalanine |
763721 |
