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Information on EC 1.4.3.2 - L-amino-acid oxidase
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1.4.3.2 L-amino-acid oxidaseIUBMB Comments
A flavoprotein (FAD).
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Word Map
- 1.4.3.2
- appendage
- atrial
-
occlusion
- fibrillation
- venom
- stroke
- snake
-
anticoagulation
-
bleeding
-
percutaneous
-
amplatzer
-
thromboembolic
-
watchman
-
transesophageal
-
contraindication
-
cha2ds2-vasc
-
has-bled
-
amulet
-
non-valvular
- bothrops
- hare
-
device-related
- tamponade
-
periprocedural
- crotalus
-
lariat
-
fluoroscopy
- agkistrodon
-
chads2
-
procedure-related
- antivenoms
-
transseptal
- rhodostoma
- calloselasma
-
noacs
-
post-procedural
- auricularia
- medicine
- atrox
- synthesis
- drug development
- moojeni
- adamanteus
The enzyme appears in viruses and cellular organisms
Synonyms
laao, il4i1, l-amino-acid oxidase, l-aao, escapin, dolabellanin, l-phenylalanine oxidase, akbu-laao, m-lao, toxophallin, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AAD
escapin
IL4I1
Il4i1 protein
Interleukin Four Induced Gene 1 protein
-
first described in the mouse, characterized in human B cells, expression is restricted to lymphoid tissues and induced by interleukin-4
L-AAO
L-amino acid oxidase
L-amino acid: O2 oxidoreductase
L-Aox
LAAO
LAAO-I
LAAOI
LAO
M-LAO
Pm1
SSAP
Il4i1 protein
-
secreted L-phenylalanine oxidase, physiologically expressed by myeloid cells, gene expression in primary mediastinal B-cell lymphoma
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2
mechanism
-
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2
mechanism
-
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2
ping-pong mechanism with binary complexes, derived from kinetic data
-
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2
allosteric effects, activation energy
-
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2
hydride transfer mechanism
-
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2
reaction mechanism. Catalytic amino acids are H223 in two conformations, G464 and R322
-
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Alanine, aspartate and glutamate metabolism, Biosynthesis of secondary metabolites, Cysteine and methionine metabolism, Isoquinoline alkaloid biosynthesis, Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Tryptophan metabolism, Tyrosine metabolism, Valine, leucine and isoleucine degradation
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SYSTEMATIC NAME
IUBMB Comments
L-amino-acid:oxygen oxidoreductase (deaminating)
A flavoprotein (FAD).
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CAS REGISTRY NUMBER
COMMENTARY
9000-89-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O + O2
2-oxo-3-[(1,1,2,2-tetrafluoroethyl)sulfanyl]propanoic acid + NH3 + H2O2
-
80% of the activity with L-methionine
-
?
3,4-dihydroxyphenyl-L-Ala + H2O + O2
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + NH3 + H2O2
-
-
-
?
alpha-hydroxyisocaproic acid + H2O + O2
2-oxo-4-methylpentanoic acid + NH3 + H2O2
-
-
-
?
alpha-hydroxyvaleric acid + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
an L-amino acid + H2O + O2
a 2-oxo-acid + NH3 + H2O2
-
L-amino-acid oxidase catalyzes the oxidative deamination of a number of L-amino acids to their respective imino acids with concomitant hydrolysis to alpha-keto acids, together with the production of ammonia and hydrogen peroxide
-
?
DL-3-(1-pyridyl)-alanine + H2O + O2
? + NH3 + H2O2
24% of the activity compared to L-alanine
-
?
DL-3-(1-pyridyl)alanine + H2O + O2
3-(1-pyridyl)pyruvate + NH3 + H2O2
24% of the activity with L-Ala
-
?
DL-4-fluorophenylalanine + H2O + O2
(4-fluorophenyl)pyruvate + NH3 + H2O2
25% of the activity with L-Ala
-
?
DL-4-fluorophenylalanine + H2O + O2
? + NH3 + H2O2
25% of the activity compared to L-alanine
-
?
DL-Ala + H2O + O2
2-oxopropanoic acid + NH3 + H2O2
-
42% activity compared to DL-Tyr
-
?
DL-asparagine + H2O + O2
2-oxosuccinamic acid + NH3 + H2O2
-
low activity
-
?
DL-beta-phenylserine + H2O + O2
? + NH3 + H2O2
8% of the activity with L-Ala
-
?
DL-homophenylalanine + H2O + O2
2-oxo-4-phenylbutanoic acid + NH3 + H2O2
50% of the activity compared to L-alanine
-
?
DL-homophenylalanine + H2O + O2
2-oxo-4-phenylbutyric acid + NH3 + H2O2
50% of the activity with L-Ala
-
?
DL-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
55.6% activity compared to DL-Tyr
-
?
DL-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
?
DL-phenylseine + H2O + O2
? + NH3 + H2O2
8% of the activity compared to L-alanine
-
?
DL-threonine + H2O + O2
2-oxo-3-hydroxybutanoic acid + NH3 + H2O2
-
low activity
-
?
DL-tryptophan + H2O + O2
3-(1H-indol-3-yl)-2-oxopropanoic acid + NH3 + H2O2
-
low activity
-
?
DL-Tyr + H2O + O2
4-hydroxyphenylpyruvate + NH3 + H2O2
-
best substrates
-
?
Gly + H2O + O2
glyoxylate + NH3 + H2O2
-
17.8% activity compared to L-Lys
-
?
L-2-4,4,dimethylvaleric acid + H2O + O2
? + NH3 + H2O2
46% of the activity compared to L-alanine
-
?
L-2-amino-4,4-dimethylhexanoic acid + H2O + O2
4,4-dimethyl-2-oxopentanoic acid + NH3 + H2O2
44% of the activity with L-Ala
-
?
L-2-amino-4,4-dimethylvaleric acid + H2O + O2
4,4-dimethyl-2-oxopentanoic acid + NH3 + H2O2
46% of the activity with L-Ala
-
?
L-2-amino-5,5-dimethylhexanoic acid + H2O + O2
? + NH3 + H2O2
44% of the activity compared to L-alanine
-
?
L-2-chlorophenylalanine + H2O + O2
(2-chlorophenyl)pyruvate + NH3 + H2O2
24% of the activity with L-Ala
-
?
L-2-chlorophenylalanine + H2O + O2
? + NH3 + H2O2
24% of the activity compared to L-alanine
-
?
L-3-(1-naphthyl)alanine + H2O + O2
3-(1-naphthyl)pyruvate + NH3 + H2O2
109% of the activity with L-Ala
-
?
L-3-(naphthyl)alanine + H2O + O2
? + NH3 + H2O2
109% of the activity compared to L-alanine
-
?
L-4-aminophenylalanine + H2O + O2
(4-aminophenyl)pyruvate + NH3 + H2O2
16% of the activity with L-Ala
-
?
L-4-aminophenylalanine + H2O + O2
? + NH3 + H2O2
16% of the activity compared to L-alanine
-
?
L-4-chlorophenylalanine + H2O + O2
(4-chlorophenyl)pyruvate + NH3 + H2O2
9% of the activity with L-Ala
-
?
L-4-chlorophenylalanine + H2O + O2
? + NH3 + H2O2
9% of the activity compared to L-alanine
-
?
L-4-nitrophenylalanine + H2O + O2
(4-nitrophenyl)pyruvate + NH3 + H2O2
30% of the activity with L-Ala
-
?
L-4-nitrophenylalanine + H2O + O2
? + NH3 + H2O2
30% of the activity compared to L-alanine
-
?
L-Ala + H2O + O2
2-oxocaproate + NH3 + H2O2
-
21.2% activity compared to L-Lys
-
?
L-albizziin + H2O + O2
alpha-keto-beta-ureidopropionic acid + NH3 + H2O2
-
L-alpha-amino-beta-ureidopropionic acid
-
?
L-Arg + H2O + O2
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
-
the substrate is not effectively oxidized
-
?
L-Arg + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
-
?
L-Asp + H2O + O2
? + NH3 + H2O2
11% of the activity with L-Ala
-
?
L-Asp + H2O + O2
alpha-ketosuccinamic acid + NH3 + H2O2
97% of the activity with L-Ala
-
?
L-citrulline + H2O + O2
? + NH3 + H2O2
74% of the activity compared to L-alanine
-
?
L-citrulline + H2O + O2
N5-carbamoyl-2-oxopentanoic acid + NH3 + H2O2
74% of the activity with L-Ala
-
?
L-cysteine + H2O + O2
2-oxo-3-thiopropanoate + NH3 + H2O2
-
about 55% activity compared to L-methionine
-
?
L-glutamine + H2O + O2
5-amino-2,5-dioxopentanoate + NH3 + H2O2
-
about 11% activity compared to L-methionine
-
?
L-Ile + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
about 60% activity compared to L-Met
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxo-pentanoate + NH3 + H2O2
-
substrate affinity in decreasing order: L-methionine, L-tryptophan, L-leucine, L-histidine, L-phenylalanine, L-arginine, L-isoleucine
-
?
L-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
best substrate
-
?
L-leucine + H2O + O2
2-oxo-4-methylpentanoate + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
about 99% activity compared to L-methionine
-
?
L-leucine methyl ester + H2O + O2
methyl 2-oxo-4-methylpentanoate + NH3 + H2O2
-
61% activity compared to L-Arg
-
?
L-methionine methyl ester + H2O + O2
methyl 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
12% activity compared to L-Arg
-
?
L-Orn + H2O + O2
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
?
L-phenylalanine + O2
phenylpyruvate + NH3 + H2O2
-
inhibition of T cell proliferation through phenylalanine degradation
activity measurement by measuring H2O2 production
?
L-phenylalanine methyl ester + H2O + O2
methyl phenylpyruvate + NH3 + H2O2
-
67% activity compared to L-Arg
-
?
L-phenylglycine + H2O + O2
? + NH3 + H2O2
5% of the activity compared to L-alanine
-
?
L-phenylglycine + H2O + O2
phenylacetate + NH3 + H2O2
5% of the activity with L-Ala
-
?
L-Pro + H2O + O2
? + NH3 + H2O2
-
less than 10% of the activity with L-Phe
-
?
L-propargylglycine + H2O + O2
2-oxopent-4-ynoic acid + NH3 + H2O2
-
-
-
?
L-serine + H2O + O2
3-hydroxy-2-oxopropanoate + NH3 + H2O2
-
about 12% activity compared to L-methionine
-
?
L-threonine + H2O + O2
3-hydroxy-2-oxobutanoate + NH3 + H2O2
-
about 11% activity compared to L-methionine
-
?
L-tryptophan + H2O + O2
3-(1H-indol-3-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
L-tryptophan + H2O + O2
indole-3-pyruvate + NH3 + H2O2
-
about 55% activity compared to L-methionine
-
?
L-tyrosine + H2O + O2
3-(4-hydroxyphenyl)-2-oxopropanoate + NH3 + H2O2
-
about 68% activity compared to L-methionine
-
?
L-tyrosine + H2O + O2
3-(4-hydroxyphenyl)pyruvate + NH3 + H2O2
-
-
-
r
L-Val + H2O + O2
3-methyl-2-oxobutanoate + NH3 + H2O2
-
the substrate is not effectively oxidized
-
?
L-valine + H2O + O2
3-methyl-2-oxobutanoate + NH3 + H2O2
-
about 22% activity compared to L-methionine
-
?
lysine + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
low activity
-
?
Nalpha-benzyloxycarbonyl-L-lysine + H2O + O2
Nalpha-benzyloxycarbonyl-L-aminoadipic delta-semialdehyde + NH3 + H2O2
-
-
-
?
Nepsilon-acetyl-L-Lys + H2O + O2
6-acetylamino-2-oxohexanoic acid + NH3 + H2O2
46% of the activity with L-Ala
-
?
Nepsilon-acetyl-L-lysine + H2O + O2
2-oxo-6-acetylaminohexanoic acid + NH3 + H2O2
-
-
-
?
Nepsilon-acetyl-L-lysine + H2O + O2
? + NH3 + H2O2
46% of the activity compared to L-alanine
-
?
S-allyl-L-cysteine + H2O + O2
2-oxo-3-(prop-2-en-1-ylsulfanyl)propanoic acid + NH3 + H2O2
-
94% of the activity with L-methionine
-
?
S-allylmercapto-L-cysteine + H2O + O2
2-oxo-3-[(2-thioxoethyl)sulfanyl]propanoic acid + NH3 + H2O2
-
26% of the activity with L-methionine
-
?
S-benzothiazolyl-L-cysteine + H2O + O2
3-(1,3-benzothiazol-3(2H)-ylsulfanyl)-2-oxopropanoic acid + NH3 + H2O2
-
161% of the activity with L-methionine
-
?
S-methylmercapto-L-cysteine + H2O + O2
? + NH3 + H2O2
-
66% of the activity with L-methionine
-
?
S-penta-1,3-dienylmercapto-L-cysteine + H2O + O2
? + NH3 + H2O2
-
7% of the activity with L-methionine
-
?
S-propylmercapto-L-cysteine + H2O + O2
2-oxo-3-[(3-thioxopropyl)sulfanyl]propanoic acid + NH3 + H2O2
-
16% of the activity with L-methionine
-
?
thyroxine + H2O + O2
3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylpyruvate] + NH3 + H2O2
-
-
-
?
triiodothyronine + H2O + O2
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
DL-norleucine + H2O + O2
2-oxocaproate + NH3 + H2O2
-
53% activity compared to L-Arg
-
?
DL-norleucine + H2O + O2
alpha-ketocaproate + NH3 + H2O2
73% of the activity compared to L-alanine
-
?
DL-norleucine + H2O + O2
alpha-ketocaproate + NH3 + H2O2
73% of the activity with L-Ala
-
?
DL-O-methylserine + H2O + O2
? + NH3 + H2O2
99% of the activity compared to L-alanine
-
?
DL-O-methylserine + H2O + O2
? + NH3 + H2O2
99% of the activity with L-Ala
-
?
L-2,3-diaminopropionic acid + H2O + O2
? + NH3 + H2O2
71% of the activity compared to L-alanine
-
?
L-2,3-diaminopropionic acid + H2O + O2
? + NH3 + H2O2
71% of the activity with L-Ala
-
?
L-2,4-diaminobutyric acid + H2O + O2
4-amino-2-oxobutanoate + NH3 + H2O2
100% of the activity compared to L-alanine
-
?
L-2,4-diaminobutyric acid + H2O + O2
4-amino-2-oxobutanoate + NH3 + H2O2
as active as L-Ala
-
?
L-Ala + H2O + O2
2-oxo-3-propanoate + NH3 + H2O2
-
lowest activity
-
?
L-Ala + H2O + O2
2-oxo-3-propanoate + NH3 + H2O2
-
the substrate is not effectively oxidized
-
?
L-Ala + H2O + O2
2-oxopropanoic acid + NH3 + H2O2
-
54.1% activity compared to DL-Tyr
-
?
L-alanine + H2O + O2
2-oxopropanoic acid + NH3 + H2O2
highly enantioselective enzyme with a broad substrate specificity
-
?
L-alanine + H2O + O2
2-oxopropanoic acid + NH3 + H2O2
highly enantioselective enzyme with a broad substrate specificity
-
?
L-alpha-aminobutyric acid + H2O + O2
alpha-ketobutyrate + NH3 + H2O2
-
-
-
?
L-alpha-aminobutyric acid + H2O + O2
alpha-ketobutyrate + NH3 + H2O2
-
low reaction rate
-
?
L-alpha-aminobutyric acid + H2O + O2
alpha-ketobutyrate + NH3 + H2O2
-
low reaction rate
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
-
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
all amino acids except cysteine
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
operates as scavanger of ammonium from extracellular amino acids
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
utilization of amino acids as nitrogen source
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
utilization of amino acids as nitrogen source
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
-
389803, 391766, 391770, 391774, 391776, 391777, 391778, 391779, 391782, 391783, 391790, 391791, 391792, 391793, 391795, 391797, 391799, 391800, 391804
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
bactericidal action of L-amino acid oxidase
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
cell death induced by the enzyme is of two types, one non-apoptotic and the other apoptotic. The effect is not dependent on the acute toxicity of H2O2
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
responsible for killing bacteria in the mammary gland
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
-
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
-
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
other electron acceptors: methylene blue
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
snake
-
biological functions of snake venom enzymes
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
-
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
first step in reaction sequence of formation of phenylacetic acid from L-phenylalanine
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
functional in photosynthetic and respiratory activities as well as in L-arginine degradation
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
involved in the water-splitting reaction of photosystem II
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
-
involved in the water-splitting reaction of photosystem II
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
27.6% activity compared to L-Lys
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
27.6% activity compared to L-Lys
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
best substrate
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
100% activity
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
70% of the activity with L-Ala
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinopentanoic acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinopentanoic acid + NH3 + H2O2
Rhodococcus sp. AIU Z-35-1
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
Bacillus carotarum
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
Bacillus carotarum 2Pfa
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
about 10% activity compared to L-methionine
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
substrate affinity in decreasing order: L-methionine, L-tryptophan, L-leucine, L-histidine, L-phenylalanine, L-arginine, L-isoleucine
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
good substrate
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
51.2% of the activity with L-histidine
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
51.2% of the activity with L-histidine
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
low reaction rate
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
low reaction rate
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
low reaction rate
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
low enzyme activity
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
low enzyme activity
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
low enzyme activity
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
low enzyme activity
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
70% of the activity compared to L-alanine
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
Synechococcus cedrorum PCC 6908
-
best substrate, 100% substrate specificity
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
best substrate, 100% substrate specificity
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
-
-
?
L-arginine + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
best substrate, 100% substrate specificity
-
?
L-arginine + H2O + O2
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
-
about 20% activity compared to L-methionine
-
?
L-arginine + H2O + O2
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
-
6% activity compared to L-lysine
-
?
L-arginine + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
r
L-arginine + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
r
L-Asn + H2O + O2
2-oxosuccinamic acid + NH3 + H2O2
-
about 9% activity compared to L-Met
-
?
L-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
-
13.2% activity compared to DL-Tyr
-
?
L-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
-
19.8% activity compared to L-Lys
-
?
L-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
-
1.0% activity compared to L-Arg
-
?
L-asparagine + H2O + O2
alpha-ketosuccinamic acid + NH3 + H2O2
-
-
-
?
L-asparagine + H2O + O2
alpha-ketosuccinamic acid + NH3 + H2O2
-
very low activity
-
?
L-asparagine + H2O + O2
alpha-ketosuccinamic acid + NH3 + H2O2
97% of the activity compared to L-alanine
-
?
L-asparagine + H2O + O2
alpha-ketosuccinamic acid + NH3 + H2O2
-
-
-
?
L-aspartic acid + H2O + O2
oxaloacetate + NH3 + H2O2
-
low activity
-
?
L-aspartic acid + H2O + O2
oxaloacetate + NH3 + H2O2
-
low activity
-
?
L-aspartic acid + H2O + O2
oxaloacetate + NH3 + H2O2
11% of the activity compared to L-alanine
-
?
L-Cys + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
29.5% activity compared to L-Lys
-
?
L-Cys + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
-
-
?
L-cysteic acid + H2O + O2
? + NH3 + H2O2
34% of the activity compared to L-alanine
-
?
L-cysteic acid + H2O + O2
? + NH3 + H2O2
34% of the activity with L-Ala
-
?
L-cysteine + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
-
-
?
L-cysteine + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
40% of the activity with L-methionine
-
?
L-cysteine + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
Crotalus terrificus terrificus
-
-
-
?
L-cysteine + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
-
-
?
L-cystine + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
Crotalus terrificus terrificus
-
-
-
r
L-cystine + H2O + O2
2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
104% of the activity compared to L-alanine
-
?
L-cystine + H2O + O2
? + NH3 + H2O2
-
35% of the activity with L-methionine
-
?
L-cystine + H2O + O2
? + NH3 + H2O2
104% of the activity with L-Ala
-
?
L-Gln + H2O + O2
2-oxoglutarate + NH3 + H2O2
52% of the activity with L-Ala
-
?
L-Glu + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
15.5% activity compared to L-Lys
-
?
L-Glu + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
15.5% activity compared to L-Lys
-
?
L-Glu + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
1.6% activity compared to L-Arg
-
?
L-Glu + H2O + O2
2-oxoglutarate + NH3 + H2O2
52% of the activity with L-Ala
-
?
L-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
low activity
-
?
L-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
low activity
-
?
L-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
low activity
-
?
L-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
-
-
?
L-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
-
-
?
L-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
high enzyme activity
-
?
L-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
52% of the activity compared to L-alanine
-
?
L-glutamine + H2O + O2
2-oxo-4-carbamoylbutanoic acid + NH3 + H2O2
-
-
-
?
L-glutamine + H2O + O2
2-oxo-4-carbamoylbutanoic acid + NH3 + H2O2
Rhodococcus sp. AIU Z-35-1
-
-
-
?
L-glutamine + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
10% of the activity with L-methionine
-
?
L-glutamine + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
about 5% activity compared to L-methionine
-
?
L-glutamine + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
very low activity
-
?
L-glutamine + H2O + O2
2-oxoglutarate + NH3 + H2O2
-
high enzyme activity
-
?
L-glutamine + H2O + O2
2-oxopropanoic acid + NH3 + H2O2
52% of the activity compared to L-alanine
-
?
L-His + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
-
-
?
L-His + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
-
-
?
L-His + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
-
?
L-His + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
-
-
?
L-His + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
5.2% activity compared to L-Arg
-
?
L-His + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
-
-
?
L-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
?
L-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
36% of the activity with L-Ala
-
?
L-histidine + H2O + O2
2-oxo-3-[4-imidazolyl]-propanoate + NH3 + H2O2
-
-
-
r
L-histidine + H2O + O2
2-oxo-3-[4-imidazolyl]-propanoate + NH3 + H2O2
-
-
-
r
L-histidine + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
low activity
-
?
L-histidine + H2O + O2
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
about 19% activity compared to L-methionine
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
substrate affinity in decreasing order: L-phenylalanine, L-tyrosine, L-tryptophan, L-leucine, L-methionine, L-isoleucine, L-valine, L-histidine
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
substrate affinity in decreasing order: L-methionine, L-tryptophan, L-leucine, L-histidine, L-phenylalanine, L-arginine, L-isoleucine
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
low reaction rate
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
low reaction rate
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
low reaction rate
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
low enzyme activity
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
low enzyme activity
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
low enzyme activity
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
low enzyme activity
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
36% of the activity compared to L-alanine
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
Synechococcus cedrorum PCC 6908
-
poor substrate, less than 2% substrate specificity
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
poor substrate, less than 2% substrate specificity
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
-
-
?
L-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
-
poor substrate, less than 2% substrate specificity
-
?
L-homocysteine + H2O + O2
4-thio-2-ketobutyric acid + NH3 + H2O2
Crotalus terrificus terrificus
-
-
-
?
L-homocysteine + H2O + O2
4-thio-2-ketobutyric acid + NH3 + H2O2
-
-
-
?
L-homocysteine thiolactone + H2O + O2
? + NH3 + H2O2
23% of the activity compared to L-alanine
-
?
L-homocysteine thiolactone + H2O + O2
? + NH3 + H2O2
23% of the activity with L-Ala
-
?
L-homoserine lactone + H2O + O2
? + NH3 + H2O2
66% of the activity compared to L-alanine
-
?
L-homoserine lactone + H2O + O2
? + NH3 + H2O2
66% of the activity with L-Ala
-
?
L-Ile + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
-
-
?
L-Ile + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
-
?
L-Ile + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
-
-
?
L-Ile + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
3.1% activity compared to L-Arg
-
?
L-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
45% of the activity with L-Ala
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
substrate affinity in decreasing order: L-phenylalanine, L-tyrosine, L-tryptophan, L-leucine, L-methionine, L-isoleucine, L-valine, L-histidine
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
-
low enzyme activity
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
about 68% activity compared to L-methionine
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
r
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
about 35% activity compared to L-methionine
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
high substrate activity
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high catalytic activity
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
?
L-isoleucine + H2O + O2
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
-
-
-
?
L-isoleucine + H2O + O2
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
-
low reaction rate
-
?
L-isoleucine + H2O + O2
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
-
low reaction rate
-
?
L-isoleucine + H2O + O2
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
-
low reaction rate
-
?
L-isoleucine + H2O + O2
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
45% of the activity compared to L-alanine
-
?
L-isoleucine + H2O + O2
alpha-keto-beta-methyl-pentanoic acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
70% activity compared to L-Arg
-
?
L-Leu + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
LAAOs are flavoenzymes catalyzing the stereospecifically oxidative deamination of a wide range of L-amino acids
-
?
L-Leu + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
?
L-Leu + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
68% of the activity with L-Ala
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
about 97% activity compared to L-methionine
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
no reaction with D-leucine
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
Bacillus carotarum 2Pfa
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
high substrate activity, most specific substrate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high affinity for the substrate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
substrate affinity in decreasing order: L-phenylalanine, L-tyrosine, L-tryptophan, L-leucine, L-methionine, L-isoleucine, L-valine, L-histidine
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
Bothrops sp.
-
high reaction rate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
substrate affinity in decreasing order: L-methionine, L-leucine, L-phenylalanine, L-tyrosine, L-tryptophan
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high reaction rate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
one of the best substrates
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
substrate affinity in decreasing order: L-methionine, L-tryptophan, L-leucine, L-histidine, L-phenylalanine, L-arginine, L-isoleucine
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
good substrate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high reaction rate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high reaction rate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high reaction rate
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high enzyme activity
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high enzyme activity
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high enzyme activity
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
high enzyme activity
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
68% of the activity compared to L-alanine
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-Lys + H2O + O2
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
100% activity
-
?
L-Lys + H2O + O2
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
100% activity
-
?
L-Lys + H2O + O2
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
-
-
?
L-Lys + H2O + O2
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
-
?
L-Lys + H2O + O2
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
-
?
L-Lys + H2O + O2
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
-
-
?