EC Number   |
General Information |
Reference |
|---|
    1.14.16.4 | malfunction |
enzyme-deficient mice have elevated serum tryptophan levels, a normal mast cell compartment and enhanced signaling of mammalian target of rapamycin. Enzyme deficiency exacerbates experimental autoimmune encephalomyelitis |
728061 |
| 1.14.16.4 | malfunction |
serveral single nucleotide polymorphisms are associated with depression, suicidal behavior and bipolar disorder |
716436 |
| 1.14.16.4 | metabolism |
rate-limiting enzyme in the serotonin biosynthesis |
715983 |
| 1.14.16.4 | metabolism |
tryptophan hydroxylase 1 is the rate limiting enzyme in the biosynthesis off serotonin |
744509 |
| 1.14.16.4 | physiological function |
the enzyme is a potent regulator of immunity regulating immune tolerance and inflammation. The enzyme is essential for the generation of protective T cellmediated antitumor immunity |
728061 |
| 1.14.16.4 | physiological function |
the enzyme is required for eye melanogenesis and essential for photoreceptor pigmentation after regeneration |
746183 |
| 1.14.16.4 | physiological function |
the th2 gene product is required for the synthesis of serotonin in vivo and has tryptophan hydroxylase activity in vitro |
727949 |
| 1.14.16.4 | physiological function |
TPH is a major site of hypoxia-induced down-regulation of serotonergic function in croaker brains |
705929 |
