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Literature summary for 1.14.16.4 extracted from

  • Goldberg, D.R.; De Lombaert, S.; Aiello, R.; Bourassa, P.; Barucci, N.; Zhang, Q.; Paralkar, V.; Stein, A.J.; Valentine, J.; Zavadoski, W.
    Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors (2016), Bioorg. Med. Chem. Lett., 26, 2855-2860 .
    View publication on PubMed
Search for more literature for 1.14.16.4

Inhibitors

Inhibitors Comment Organism Structure
4-([(E)-amino[([1,1'-biphenyl]-2-yl)amino]methylidene]carbamoyl)-L-phenylalanine
-
 Homo sapiens
4-([(E)-amino[([2-(piperidin-1-yl)-6-[(propan-2-yl)oxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
 Homo sapiens
4-([(E)-amino[([2-(piperidin-1-yl)-6-[2-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
 Homo sapiens
4-([(E)-amino[([2-(piperidin-1-yl)-6-[3-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
 Homo sapiens
4-([(E)-amino[([2-(piperidin-1-yl)-6-[4-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
 Homo sapiens
4-[(diaminomethylidene)carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino(benzylamino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(1H-1,2,4-triazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(1H-pyrazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(2-azabicyclo[2.2.1]heptan-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(2-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(2-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(2-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(2-methylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(2H-1,2,3-triazol-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(3,5-dimethylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(3-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(3-methyl-1H-pyrazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(3-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(3-methylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-benzylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-hydroxypiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-methoxypiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-methyl-1H-imidazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(4-phenylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(azepan-1-yl)-6-methoxyphenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(azepan-1-yl)-6-phenoxyphenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(azepan-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(azetidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(cyclobutyloxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(cyclohexyloxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(diethylamino)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(morpholin-4-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(piperidin-1-yl)-5-(1,3-thiazol-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(piperidin-1-yl)-6-(trifluoromethyl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(pyrrolidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-(thiomorpholin-4-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-chloro-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-ethoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-methoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-methyl-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[2-phenoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[3-(piperidin-1-yl)[1,1'-biphenyl]-2-yl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[3-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[3-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[3-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[4-(piperidin-1-yl)[1,1'-biphenyl]-3-yl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[4-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[4-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[4-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[5-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[5-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino([[5-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino[[([1,1'-biphenyl]-2-yl)methyl](methyl)amino]methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino[[([1,1'-biphenyl]-2-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino[[([1,1'-biphenyl]-3-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino[[([1,1'-biphenyl]-4-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino[[2-([1,1'-biphenyl]-2-yl)ethyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-amino[[3-([1,1'-biphenyl]-2-yl)propyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
4-[[(E)-[[([1,1'-biphenyl]-2-yl)methyl]amino](methylamino)methylidene]carbamoyl]-L-phenylalanine
-
 Homo sapiens
LP-533401
-
 Homo sapiens
LX-1033
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

Synonyms Comment Organism
TPH1
-
 Homo sapiens
tryptophan hydroxylase-1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000006
-
 pH and temperature not specified in the publication Homo sapiens 4-([(E)-amino[([2-(piperidin-1-yl)-6-[4-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
0.000006
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(3-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000006
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000007
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(piperidin-1-yl)-5-(1,3-thiazol-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000008
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(3-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.00001
-
 pH and temperature not specified in the publication Homo sapiens 4-([(E)-amino[([2-(piperidin-1-yl)-6-[2-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
0.00001
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(2-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000011
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(2-azabicyclo[2.2.1]heptan-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000011
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(2-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000011
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000011
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(piperidin-1-yl)-6-(trifluoromethyl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000012
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-methyl-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000013
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(azepan-1-yl)-6-phenoxyphenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000014
-
 pH and temperature not specified in the publication Homo sapiens 4-([(E)-amino[([2-(piperidin-1-yl)-6-[3-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
0.000014
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[4-(piperidin-1-yl)[1,1'-biphenyl]-3-yl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000015
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(2-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000015
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(2-methylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000015
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000016
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000016
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(azepan-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000016
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[5-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000016
-
 pH and temperature not specified in the publication Homo sapiens LX-1033
0.000017
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(piperidin-1-yl)-6-(trifluoromethyl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000018
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-methoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000019
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(azepan-1-yl)-6-methoxyphenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.00002
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(3-methylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000022
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000022
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[5-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000025
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(3,5-dimethylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000025
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[5-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000026
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-phenoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000028
-
 pH and temperature not specified in the publication Homo sapiens 4-([(E)-amino[([2-(piperidin-1-yl)-6-[(propan-2-yl)oxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
0.00003
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(cyclohexyloxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000032
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(pyrrolidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000033
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-methoxypiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000033
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-chloro-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000034
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[3-(piperidin-1-yl)[1,1'-biphenyl]-2-yl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000035
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[3-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000038
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-benzylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000043
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-ethoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000045
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000046
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[3-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000053
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(cyclobutyloxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000054
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-phenylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000058
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(thiomorpholin-4-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000061
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[4-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000061
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino[[2-([1,1'-biphenyl]-2-yl)ethyl]amino]methylidene]carbamoyl]-L-phenylalanine
0.000066
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[3-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000069
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[4-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000074
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[4-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000099
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(diethylamino)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000106
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-hydroxypiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000106
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(morpholin-4-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000129
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(azetidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000165
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino[[([1,1'-biphenyl]-2-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
0.00018
-
 pH and temperature not specified in the publication Homo sapiens LP-533401
0.000335
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(2H-1,2,3-triazol-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000405
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino[[([1,1'-biphenyl]-3-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
0.000501
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(1H-pyrazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000599
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino[[3-([1,1'-biphenyl]-2-yl)propyl]amino]methylidene]carbamoyl]-L-phenylalanine
0.000666
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(3-methyl-1H-pyrazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.000974
-
 pH and temperature not specified in the publication Homo sapiens 4-([(E)-amino[([1,1'-biphenyl]-2-yl)amino]methylidene]carbamoyl)-L-phenylalanine
0.001625
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino[[([1,1'-biphenyl]-2-yl)methyl](methyl)amino]methylidene]carbamoyl]-L-phenylalanine
0.001844
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(1H-1,2,4-triazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.002014
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-[[([1,1'-biphenyl]-2-yl)methyl]amino](methylamino)methylidene]carbamoyl]-L-phenylalanine
0.0022
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino[[([1,1'-biphenyl]-4-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
0.005107
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino([[2-(4-methyl-1H-imidazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
0.011036
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(E)-amino(benzylamino)methylidene]carbamoyl]-L-phenylalanine
0.02
-
 pH and temperature not specified in the publication Homo sapiens 4-[(diaminomethylidene)carbamoyl]-L-phenylalanine

General Information

General Information Comment Organism
metabolism tryptophan hydroxylase 1 is the rate limiting enzyme in the biosynthesis off serotonin Homo sapiens