EC Number   |
General Information |
Reference |
|---|
    1.14.14.19 | evolution |
the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 |
714352 |
| 1.14.14.19 | malfunction |
deficiency of CYP17A1 causes hypertension |
728213 |
| 1.14.14.19 | malfunction |
mutations resulting in only the 17,20-lyase deficiency are located either in the putative substrate-binding region of CYP17A1 or in the region responsible for interaction with cytochrome b5 |
714352 |
| 1.14.14.19 | malfunction |
natural mutations causing CYP17A1 deficiency, i.e. 17OHD, a rare form of congenital adrenal hyperplasia |
704824 |
| 1.14.14.19 | metabolism |
CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C21 steroids (progesterone derivatives) and delta5-C21 steroids (pregnenolone derivatives) aswell as the 17,20-lyase reaction producing C19-steroids, a key branch point in steroid hormone biosynthesis. Depending on CYP17 activity, the steroid hormone biosynthesis pathway is directed to either the formation of mineralocorticoids and glucocorticoids or sex hormones |
714352 |
| 1.14.14.19 | metabolism |
CYP17 catalyzes the last step in androgen biosynthesis |
703551 |
| 1.14.14.19 | metabolism |
Cyp17 is important in the metabolism of androgens, overview |
705395 |
| 1.14.14.19 | metabolism |
CYP17 is the key enzyme for the biosynthesis of androgens |
701962 |
| 1.14.14.19 | metabolism |
CYP17 is the key enzyme in androgen biosynthesis pathway |
706689 |
| 1.14.14.19 | metabolism |
CYP17-dependent alternative steroids biosynthesis, overview |
714352 |
