Application | Comment | Organism |
---|---|---|
drug development | CYP17 is a target for inhibitor design as a target in treatment of prostate cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
CYP17, expression in Escherichia coli, co-expression with NADPH-P450 reductase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[1-(3',4'-dimethoxy-biphenyl-4-yl)-propyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(3'-methoxy-biphenyl-4-yl)-ethyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(3'-methoxy-biphenyl-4-yl)-propyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(4'-ethoxy-biphenyl-4-yl)-propyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(4'-methoxy-biphenyl-4-yl)-ethyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(4'-methoxy-biphenyl-4-yl)-propyl]-1H-imidazole | - |
Homo sapiens | |
3'-fluoro-4'-(1-imidazol-1-yl-propyl)-biphenyl-3,4-diol | - |
Homo sapiens | |
3'-fluoro-4'-(1-imidazol-1-yl-propyl)-biphenyl-4-ol | - |
Homo sapiens | |
3-chloro-4'-(1-imidazol-1-yl-propyl)-biphenyl-4-ol | - |
Homo sapiens | |
4'-(1-imidazol-1-yl-propyl)-3,5-dimethyl-biphenyl-4-ol | - |
Homo sapiens | |
4'-(1-imidazol-1-yl-propyl)-3-methyl-biphenyl-4-ol | - |
Homo sapiens | |
4'-(1-imidazol-1-yl-propyl)-biphenyl-3,4-diol | - |
Homo sapiens | |
4'-(1-imidazol-1-yl-propyl)-biphenyl-3,5-diol | - |
Homo sapiens | |
4'-(1-imidazol-1-yl-propyl)-biphenyl-3-ol | - |
Homo sapiens | |
4'-(1-imidazol-1-yl-propyl)-biphenyl-4-ol | - |
Homo sapiens | |
abiraterone | - |
Homo sapiens | |
ketoconazole | unspecific inhibitor | Homo sapiens | |
additional information | inhibitor design and synthesis via Suzuki-cross-coupling, Grignard reaction and CDI-assisted SNt-reaction with imidazole, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CYP17 is the cytochrome b5 modulated key enzyme for the biosynthesis of androgens, catalyzing the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent cleavage of the C 20,21-acetyl group to yield the corresponding androgens dehydroepiandrosterone and androstendione | ? | - |
? | |
pregnenolone + ferrocytochrome b5 + O2 | Homo sapiens | - |
? | - |
? | |
progesterone + ferrocytochrome b5 + O2 | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CYP17 is the cytochrome b5 modulated key enzyme for the biosynthesis of androgens, catalyzing the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent cleavage of the C 20,21-acetyl group to yield the corresponding androgens dehydroepiandrosterone and androstendione | Homo sapiens | ? | - |
? | |
pregnenolone + ferrocytochrome b5 + O2 | - |
Homo sapiens | ? | - |
? | |
progesterone + ferrocytochrome b5 + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase-17,20-lyase | - |
Homo sapiens |
CYP17 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ferrocytochrome b5 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000052 | - |
- |
Homo sapiens | 3'-fluoro-4'-(1-imidazol-1-yl-propyl)-biphenyl-3,4-diol | |
0.000072 | - |
- |
Homo sapiens | abiraterone | |
0.00009 | - |
- |
Homo sapiens | 3'-fluoro-4'-(1-imidazol-1-yl-propyl)-biphenyl-4-ol | |
0.000152 | - |
- |
Homo sapiens | 4'-(1-imidazol-1-yl-propyl)-biphenyl-3,4-diol | |
0.000164 | - |
- |
Homo sapiens | 4'-(1-imidazol-1-yl-propyl)-biphenyl-3-ol | |
0.000188 | - |
- |
Homo sapiens | 1-[1-(3'-methoxy-biphenyl-4-yl)-propyl]-1H-imidazole | |
0.000195 | - |
- |
Homo sapiens | 4'-(1-imidazol-1-yl-propyl)-biphenyl-3,5-diol | |
0.000217 | - |
- |
Homo sapiens | 3-chloro-4'-(1-imidazol-1-yl-propyl)-biphenyl-4-ol | |
0.000231 | - |
- |
Homo sapiens | 4'-(1-imidazol-1-yl-propyl)-biphenyl-4-ol | |
0.000261 | - |
- |
Homo sapiens | 4'-(1-imidazol-1-yl-propyl)-3-methyl-biphenyl-4-ol | |
0.000379 | - |
- |
Homo sapiens | 4'-(1-imidazol-1-yl-propyl)-3,5-dimethyl-biphenyl-4-ol | |
0.00278 | - |
- |
Homo sapiens | ketoconazole |
General Information | Comment | Organism |
---|---|---|
metabolism | CYP17 catalyzes the last step in androgen biosynthesis | Homo sapiens |