EC Number   |
General Information |
Reference  |
|---|
   3.4.21.46 | physiological function |
PDGF-D plays an important role in breast tumor aggressiveness and this process is mechanistically linked with the activation of Notch and NF-kappaB signaling |
707940 |
| 3.4.21.46 | physiological function |
serum VEGF-D levels are greater in patients with lympangioleiomyomatosis with lymphatic involvement |
708131 |
| 3.4.21.46 | physiological function |
interleukin-7/interleukin-7R induce VEGF-D up-regulation and promote lymphangiogenesis via c-Fos/c-Jun pathway in lung cancer |
708370 |
| 3.4.21.46 | physiological function |
in total 150 gastric cancer patients who underwent radical gastrectomy are analyzed (75 cases presented with hepatic metastases and 75 cases presented without any recurrences). Significant association is shown between VEGF-D expression and hepatic metastasis from gastric cancer after radical gastrectomy |
710586 |
| 3.4.21.46 | more |
the substrate-binding, or exosite, region displays a well defined and rigid conformation. A salt bridge between Arg202 on the self-inhibitory loop and Asp177 locks the S1 pocket and rigidifies the exosite. Asp-His-Ser catalytic site. The enzyme exhibits conformational dynamics like thrombin, but unlike in thrombin a mechanism has evolved in factor D that locks the unbound native state into an ordered inactive conformation via the self-inhibitory loop. The Asp-His-Ser catalytic site of the enzyme is in an enzymatically active conformation induced by substrate binding at the exosite |
731071 |
| 3.4.21.46 | physiological function |
human factor D is a self-inhibited thrombin-like serine proteinase that is critical for amplification of the complement immune response |
731071 |
| 3.4.21.46 | physiological function |
targeting of the enzyme's exosite causes inhibition of the pathway complement activation |
732044 |
| 3.4.21.46 | metabolism |
in humans neither MASP-1 nor MASP-3 are required for alternative pathway function. During MASP-1/-3 deficiency significant alternative pathway activity remains, indicating that mature factor D is present in the absence of MASP-1/-3 |
732272 |
| 3.4.21.46 | more |
influence of buffer composition on the activity of the alternative pathway of complement activation in mice in the presence and the absence of the Masp1 gene products, overview |
732272 |
| 3.4.21.46 | physiological function |
mature factor D is required for the alternative complement pathway |
732272 |
