BRENDA - Enzyme Database show
show all sequences of 3.4.21.46

Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways

Ahmad, A.; Wang, Z.; Kong, D.; Ali, R.; Ali, S.; Banerjee, S.; Sarkar, F.H.; Breast Cancer Res. Treat. 126, 15-25 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in breast cancer cell lines MDA-MB-468 and MCF-7 cells
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
breast cancer cell line
PDGF-D high-expressing breast cancer cell line SUM-149 is more invasive compared to low-expressing cell lines
Homo sapiens
-
MCF-7 cell
low PDGF-D expressing breast cancer cell line is less invasive
Homo sapiens
-
MDA-MB-231 cell
PDGF-D expressing breast cancer cell lines are more invasive compared to non-expressing cell lines
Homo sapiens
-
MDA-MB-468 cell
low PDGF-D expressing breast cancer cell line is less invasive
Homo sapiens
-
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in breast cancer cell lines MDA-MB-468 and MCF-7 cells
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
breast cancer cell line
PDGF-D high-expressing breast cancer cell line SUM-149 is more invasive compared to low-expressing cell lines
Homo sapiens
-
MCF-7 cell
low PDGF-D expressing breast cancer cell line is less invasive
Homo sapiens
-
MDA-MB-231 cell
PDGF-D expressing breast cancer cell lines are more invasive compared to non-expressing cell lines
Homo sapiens
-
MDA-MB-468 cell
low PDGF-D expressing breast cancer cell line is less invasive
Homo sapiens
-
Expression
Organism
Commentary
Expression
Homo sapiens
silencing the expression of PDGF-D by siRNA in PDGF-D high expressing MDA-MB-231 and SUM-149 cells shows decreased cell proliferation and increased apoptosis
down
Homo sapiens
overexpression of PDGF-D in PDGF-D low expressing breast cancer cell lines MDA-MB-468 and MCF-7 cells by cDNA transfection shows increased cell proliferation. PDGF-D overexpression is positively correlated with the expression of Notch-1 and Jagged-1, and the expression of mesenchymal markers (Vimentin and ZEB-2) with concomitant decreased expression of epithelial marker E-cadherin. PDGF-D over-expression leads to increased DNA binding activity of NF-kappaB
up
General Information
General Information
Commentary
Organism
physiological function
PDGF-D plays an important role in breast tumor aggressiveness and this process is mechanistically linked with the activation of Notch and NF-kappaB signaling
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
PDGF-D plays an important role in breast tumor aggressiveness and this process is mechanistically linked with the activation of Notch and NF-kappaB signaling
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
silencing the expression of PDGF-D by siRNA in PDGF-D high expressing MDA-MB-231 and SUM-149 cells shows decreased cell proliferation and increased apoptosis
down
Homo sapiens
overexpression of PDGF-D in PDGF-D low expressing breast cancer cell lines MDA-MB-468 and MCF-7 cells by cDNA transfection shows increased cell proliferation. PDGF-D overexpression is positively correlated with the expression of Notch-1 and Jagged-1, and the expression of mesenchymal markers (Vimentin and ZEB-2) with concomitant decreased expression of epithelial marker E-cadherin. PDGF-D over-expression leads to increased DNA binding activity of NF-kappaB
up
Other publictions for EC 3.4.21.46
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732521
Cresci
Alternative complement pathway ...
Mus musculus, Mus musculus C57BL/6
Mol. Immunol.
64
9-17
2015
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731071
Forneris
Ensemble refinement shows conf ...
Homo sapiens
Acta Crystallogr. Sect. D
70
733-743
2014
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732272
Degn
The pro-Factor D cleaving acti ...
Mus musculus
J. Immunol.
192
5448-5449
2014
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3
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732044
Katschke
Inhibiting alternative pathway ...
Homo sapiens, Macaca fascicularis
J. Biol. Chem.
287
12886-12892
2012
-
2
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2
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2
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2
2
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707940
Ahmad
Platelet-derived growth factor ...
Homo sapiens
Breast Cancer Res. Treat.
126
15-25
2011
-
-
1
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1
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2
1
1
2
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708769
Hu
Deguelin-an inhibitor to tumor ...
Homo sapiens
Int. J. Cancer
127
2455-2466
2010
-
1
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1
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1
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709321
Takahashi
Essential role of mannose-bind ...
Mus musculus
J. Exp. Med.
207
29-37
2010
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718398
Forneris
Structures of C3b in complex w ...
Homo sapiens
Science
330
1816-1820
2010
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695580
Li
Vascular endothelial growth fa ...
Homo sapiens
Anat. Rec. (Hoboken)
292
562-569
2009
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1
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698902
Toivanen
Novel vascular endothelial gro ...
Homo sapiens
J. Biol. Chem.
284
16037-1648
2009
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1
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13
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699302
Kinnunen
Baculovirus is an efficient ve ...
Homo sapiens
J. Gene Med.
11
382-389
2009
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708131
Glasgow
Serum vascular endothelial gro ...
Homo sapiens
Chest
135
1293-1300
2009
-
1
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1
1
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708370
Ming
Interleukin 7/interleukin 7 re ...
Homo sapiens
Eur. J. Cancer
45
866-873
2009
-
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1
1
1
1
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708533
Kong
An immune responsive complemen ...
Paralichthys olivaceus
Fish Shellfish Immunol.
27
486-492
2009
-
-
-
-
-
-
-
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1
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8
-
1
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8
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8
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1
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1
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710586
Deng
Vascular endothelial growth fa ...
Homo sapiens
Surgery
146
896-905
2009
-
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1
1
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697096
Schaefer
Regulation of vascular endothe ...
Homo sapiens
Cancer Res.
68
457-466
2008
1
1
1
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7
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7
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698194
Liu
Identification of platelet-der ...
Homo sapiens
Hum. Pathol.
39
393-402
2008
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1
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683539
Luginbuehl
Complement factor D, albumin, ...
Homo sapiens
Infect. Immun.
75
1771-1777
2007
-
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668074
Sprong
Deficient alternative compleme ...
Homo sapiens
Blood
107
4865-4870
2006
-
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2
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683526
Lovoll
Maternal transfer of complemen ...
Oncorhynchus mykiss
Immunogenetics
58
168-179
2006
-
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669356
Harris
Molecular dissection of intera ...
Homo sapiens
J. Biol. Chem.
280
2569-2578
2005
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1
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668289
Oda
Analysis of protein absorbed b ...
Homo sapiens
Clin. Chim. Acta
342
155-160
2004
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1
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2
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1
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670101
Elliott
Effects of complement factor D ...
Mus musculus
Kidney Int.
65
129-138
2004
-
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1
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4
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2
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2
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670498
Recinos
Liver gene expression associat ...
Mus musculus
Physiol. Genomics
19
131-142
2004
-
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1
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4
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651513
Kitano
Synthesis of factor D by norma ...
Homo sapiens
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Catana
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Harper
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36580
Davis III
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Reid
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Davies
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Lesavre
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