Literature summary for 3.4.21.46 extracted from

Ahmad, A.; Wang, Z.; Kong, D.; Ali, R.; Ali, S.; Banerjee, S.; Sarkar, F.H.
Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways (2011), Breast Cancer Res. Treat., 126, 15-25.

Search for more literature for 3.4.21.46

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in breast cancer cell lines MDA-MB-468 and MCF-7 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell line	PDGF-D high-expressing breast cancer cell line SUM-149 is more invasive compared to low-expressing cell lines	Homo sapiens	-
MCF-7 cell	low PDGF-D expressing breast cancer cell line is less invasive	Homo sapiens	-
MDA-MB-231 cell	PDGF-D expressing breast cancer cell lines are more invasive compared to non-expressing cell lines	Homo sapiens	-
MDA-MB-468 cell	low PDGF-D expressing breast cancer cell line is less invasive	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PDGF-D	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	silencing the expression of PDGF-D by siRNA in PDGF-D high expressing MDA-MB-231 and SUM-149 cells shows decreased cell proliferation and increased apoptosis	down
Homo sapiens	overexpression of PDGF-D in PDGF-D low expressing breast cancer cell lines MDA-MB-468 and MCF-7 cells by cDNA transfection shows increased cell proliferation. PDGF-D overexpression is positively correlated with the expression of Notch-1 and Jagged-1, and the expression of mesenchymal markers (Vimentin and ZEB-2) with concomitant decreased expression of epithelial marker E-cadherin. PDGF-D over-expression leads to increased DNA binding activity of NF-kappaB	up

General Information

General Information	Comment	Organism
physiological function	PDGF-D plays an important role in breast tumor aggressiveness and this process is mechanistically linked with the activation of Notch and NF-kappaB signaling	Homo sapiens

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Release 2023.1 (January 2023)