EC Number   |
General Information |
Reference |
|---|
   3.1.4.41 | physiological function |
the enzyme activity is necessary to promote arcanolysin-mediated hemolysis of erythrocytes in both time- and concentration-dependent manners |
-, 752303 |
| 3.1.4.41 | physiological function |
the enzyme inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current. Corynebacterium pseudotuberculosis has the ability to suppress the activity of the store-operated Ca2+ entry channel Orai1 with the enzyme to create an acquired, chronic severe combined immunodeficiency-like condition that allows persistent infection |
751246 |
| 3.1.4.41 | physiological function |
the enzyme is a toxic component of Loxosceles venom that activates human blood leukocytes in a partially complement-dependent manner, which can contribute to the systemic inflammation that follows envenomation by the spider |
751580 |
| 3.1.4.41 | physiological function |
the enzyme is responsible for the dermonecrosis and systemic effects observed in loxoscelism |
750196 |
| 3.1.4.41 | physiological function |
the reaction products of the enzyme promote cell migration and inflammation |
752304 |
| 3.1.4.41 | physiological function |
toxin phospholipases-D in the venom of Loxosceles spiders is the main responsible for local and systemic effects observed in the loxoscelism |
715398 |
