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Literature summary for 3.1.4.41 extracted from
- Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current (2015), J. Gen. Physiol., 146, 161-172 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | Corynebacterium pseudotuberculosis | - |
ceramide 1-phosphate + choline | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium pseudotuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | - |
Corynebacterium pseudotuberculosis | ceramide 1-phosphate + choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SMase D | - |
Corynebacterium pseudotuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current. Corynebacterium pseudotuberculosis has the ability to suppress the activity of the store-operated Ca2+ entry channel Orai1 with the enzyme to create an acquired, chronic severe combined immunodeficiency-like condition that allows persistent infection | Corynebacterium pseudotuberculosis |
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