EC Number   |
General Information |
Reference |
|---|
    2.4.1.122 | more |
C1GALT1 is overexpressed in various human malignancies |
759872 |
| 2.4.1.122 | physiological function |
C1GalTA is required for nervous system morphogenesis, C1GalTA is required for laminin O-glycosylation |
703369 |
| 2.4.1.122 | physiological function |
core 1 beta1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human malignancies with a role in head and neck squamous cell carcinoma (HNSCC). Enzyme C1GALT1 seems to promote in vitro disease progression in ovarian cancer. C1GALT1 modifies O-glycans on epidermal growth factor receptor (EGFR). C1GALT1 regulates phosphorylation, EGF-binding affinity, and O-glycosylation of EGFR to enhance malignant phenotypes in HNSCC cells. C1GALT1 regulates EGF-binding affinity of EGFR in HNSCC cells. C1GALT1 transfers galactose to Tn antigen to form T antigen. C1GALT1 is overexpressed in head and neck squamous cell carcinoma (HNSCC) tumors and high C1GALT1 expression predicts poor prognosis |
759356 |
| 2.4.1.122 | physiological function |
core 1 beta1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation. C1GALT1 regulates phosphorylation, EGF-binding affinity, and O-glycosylation of EGFR to enhance malignant phenotypes in HNSCC cells. Itraconazole blocks C1GALT1-mediated malignant phenotypes and EGFR activity, overview. C1GALT1 transfers galactose to Tn antigen to form T antigen |
759872 |
| 2.4.1.122 | physiological function |
core 1 O-glycosylation is required to maintain transcellular barrier function. Core 1 O-glycans contribute to maintenance of apical barrier function on exposed mucosal surfaces by preventing clathrin-mediated endocytosis |
723563 |
| 2.4.1.122 | physiological function |
enzyme is responsible for the synthesis and function of T antigen (mucin-type O-glycan) in vivo |
703884 |
| 2.4.1.122 | physiological function |
mucin-type protein O-glycosylation |
703895 |
| 2.4.1.122 | physiological function |
T-synthase generates core 1-derived O-glycans |
703610 |
| 2.4.1.122 | physiological function |
T-synthase is required for the generation of complex O-glycans. The O-glycosylation has been implicated in receptor signalling and cell-matrix interactions |
760113 |
| 2.4.1.122 | physiological function |
T-synthase is the key beta3-galactosyltransferase essential for biosynthesis of core 1 O-glycans (Gal beta1-3GalNAc alpha1-Ser/Thr) in animal cell glycoproteins |
704683 |
