EC Number   |
General Information  |
Reference |
|---|
   1.14.99.38 | physiological function |
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis |
726545 |
| 1.14.99.38 | physiological function |
cholesterol-25-hydroxylase acts as a broadly antiviral interferon-stimulated gene. CH25H converts cholesterol to a soluble antiviral factor, 25-hydroxycholesterol. 25-Hydroxycholesterol treatment in cultured cells broadly inhibits growth of enveloped viruses including VSV, HSV, HIV, and MHV68 and acutely pathogenic EBOV, RVFV, RSSEV, and Nipah viruses. The compound inhibits cell entry of viruses HIV and VSV, and inhibits viral protein-mediated cell-cell membrane fusion of virus NIV. 25-Hydroxycholesterol directly modifies membranes |
727611 |
| 1.14.99.38 | physiological function |
enzyme expression in human hepatoma cells restricts hepatitis C virus infection in a genotype-independent manner |
745051 |
| 1.14.99.38 | physiological function |
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol decreases the level of cytoplasmic IkBa and increases the nuclear NFkB level, its sulfated form has the opposite effects |
727109 |
| 1.14.99.38 | physiological function |
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol is, however, a weak activator of the liver X receptors. 25-Hydroxycholesterol is of great importance for maintaining cholesterol homeostasis. 25-Hydroxycholesterol induces the secretion of the proinflammatory cytokine IL-8 |
727109 |
| 1.14.99.38 | physiological function |
important role for 25-hydroxycholesterol in the immune system. High concentrations of 25-hydroxycholesterol induce apoptosis in a mouse oligodendrocyte cell line 158N in an liver X receptor-independent manner. Treatment of these cells with 25-hydroxycholesterol results in enhanced secreted phospholipase A2 activity |
727109 |
| 1.14.99.38 | physiological function |
the enzyme is a host restriction factor and part of the primary innate immune responses against hepatitis C virus infection. The enzyme inhibits hepatitis C virus infection by suppressing the maturation of sterol regulatory element-binding proteins, critical transcription factors for host lipid biosynthesis |
745657 |
| 1.14.99.38 | physiological function |
the enzyme restricts hepatitis C virus replication not only through its enzyme activity to produce 25-hydroxycholesterol but also by targeting the NS5A protein leading to the selective inhibition of NS5A dimer formation |
746435 |
