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Literature summary for 1.14.99.38 extracted from

  • Chen, Y.; Wang, S.; Yi, Z.; Tian, H.; Aliyari, R.; Li, Y.; Chen, G.; Liu, P.; Zhong, J.; Chen, X.; Du, P.; Su, L.; Qin, F.X.; Deng, H.; Cheng, G.
    Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms (2014), Sci. Rep., 4, 7242 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Huh-7.5.1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H242Q/H243Q inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + AH2 + O2 Homo sapiens
-
25-hydroxycholesterol + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q95992
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + AH2 + O2
-
Homo sapiens 25-hydroxycholesterol + A + H2O
-
?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CH25H
-
Homo sapiens
cholesterol-25-hydroxylase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme restricts hepatitis C virus replication not only through its enzyme activity to produce 25-hydroxycholesterol but also by targeting the NS5A protein leading to the selective inhibition of NS5A dimer formation Homo sapiens