EC Number |
Expression |
Reference |
---|
3.5.1.98 | down |
isoform HDAC2-2 transcript levels decline 6 h after abscisic acid treatment and show no significant difference in 24 h after abscisic acid treatment |
713221 |
3.5.1.98 | down |
K562 erythroleukemia cells treated with the HbF inducers hemin, trichostatin A, and sodium butanoate have significantly reduced mRNA levels of HDAC9 and its splice variant histone deacetylase-related protein |
719941 |
3.5.1.98 | down |
knockdown of transactive response DNA-binding protein TDP-43 downregulates histone deacetylase 6 mRNA and protein expression and reduces HDAC6 enzyme activity in non-neuronal as well as in neuronal cells |
711850 |
3.5.1.98 | down |
redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3. Covalent modification at Cys261 and Cys273 in HDAC1, coincides with attenuation of histone deacetylase activity |
712434 |
3.5.1.98 | more |
responses of GmHDACs to abscisic acid (ABA) treatment, which is the most important stress-protective phytohormone, differ. Two HD2 family genes (GmHDT2 and GmHDT4) are induced and two RPD3/HDA1 family genes (GmHDA8 and GmHDA16) are markedly suppressed, the expression of five other HDAC genes (GmHDA6, 13, 14, GmSRT2 and GmSRT4) is only slightly modulated. The status of H3K4me2 and H3K4me3 is also modulated by the both cold and heat treatments. High levels of H3K4me2 and low levels of H3K4me3 are observed following cold treatment. The level of H3K4me2 is upregulated in response to heat stress, while this treatment only has a mild effect on H3K4me3 levels |
756309 |
3.5.1.98 | up |
HDAC1 and HDAC2 protein levels are elevated in chondrocytes from osteoarthritic patients |
711956 |
3.5.1.98 | up |
hepatocyte growth factor induces HDAC-5 expression in gastric cancer cells. GO6976, a PKC inhibitor, significantly inhibits hepatocyte growth factor-induced HDAC5 expression |
713009 |
3.5.1.98 | up |
histone deacetylase 1 mRNA in pancreatic cancer tissues are significantly higher than in paracancerous tissues |
713181 |
3.5.1.98 | up |
isoform HDAC2-1 is significantly induced at 6 and 24 h after spraying of seedlings with 0.1 mM jasmonic acid, isoform HDAC2-1 shows a marked induction at 24 h after 0.1 mM abscisic acid treatment, isoform HDAC2-1 transcript levels show an increase upon treatment with 0.1 mM salicylic acid after 24 h |
713221 |
3.5.1.98 | up |
mutations of the SCF-CDC4 ubiquitin ligase complex suppress cell death by preventing the degradation of Msn2 and Msn4 transcription factors. Accumulation of transcription factors Msn2 and Msn4 leads to the induction of PNC1, which is an activator of the Sir2 histone acetylase |
719371 |