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Literature summary for 3.5.1.98 extracted from
- Upregulated histone deacetylase 1 expression in pancreatic ductal adenocarcinoma and specific siRNA inhibits the growth of cancer cells (2010), Pancreas, 39, 994-1001.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | histone deacetylase 1 is a gene therapy target in pancreatic ductal adenocarcinoma | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic ductal adenocarcinoma cell | - |
Homo sapiens | - |
| Patu-8988 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDAC1 | - |
Homo sapiens |
| histone deacetylase 1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | histone deacetylase 1 mRNA in pancreatic cancer tissues are significantly higher than in paracancerous tissues | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of HDAC1 can generate a remarkable defect in proliferation and also can significantly induce apoptosis and S-phase arrest in PaTu-8988 cells | Homo sapiens |
| physiological function | the HDAC1 overexpression plays an important role in tumorigenesis of pancreatic cancer | Homo sapiens |
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Release 2023.1 (January 2023)
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