Literature summary for 3.5.1.98 extracted from

Fiesel, F.C.; Voigt, A.; Weber, S.S.; Van den Haute, C.; Waldenmaier, A.; Goerner, K.; Walter, M.; Anderson, M.L.; Kern, J.V.; Rasse, T.M.; Schmidt, T.; Springer, W.; Kirchner, R.; Bonin, M.; Neumann, M.; Baekelandt, V.; Alunni-Fabbroni, M.; Schulz, J.B.; Kahle, P.J.
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 (2010), EMBO J., 29, 209-221.

Search for more literature for 3.5.1.98

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293-EBNA cell	-	Homo sapiens	-
SH-SY5Y cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-tubulin + H2O	major HDAC6 substrate	Homo sapiens	tubulin + acetate	-	?

Synonyms

Synonyms	Comment	Organism
HDAC6	-	Homo sapiens
histone deacetylase 6	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	knockdown of transactive response DNA-binding protein TDP-43 downregulates histone deacetylase 6 mRNA and protein expression and reduces HDAC6 enzyme activity in non-neuronal as well as in neuronal cells	down

General Information

General Information	Comment	Organism
physiological function	HDAC6 is necessary for protein aggregate formation and degradation	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)