EC Number   |
Expression |
Reference |
|---|
   3.4.21.6 | down |
activated protein C proteolytically inactivates factor Va through proteolytic cleavage and thereby downregulates prothrombinase. Factor Xa protects 17.3fold and prothrombin protects 5.8fold the inactivation of factor Va, while protein S increases the inactivation. Factor Xa and prothrombin together are highly protective, both with and without protein S. R506Q mutation of factor Va is only mildly prothrombotic, even though it profoundly affects the kinetics of inactivation of isolated FVa by activated protein C |
718415 |
| 3.4.21.6 | down |
sphingolipids, including lysosulfatide and some of its analogs like N-acetyl sulfatide, psychosine, gluco-psychosine, lyso-sphingomyelin or sulfatide, may down-regulate enzyme activity without inhibiting the enzyme's active site. Lysosulfatide is an anticoagulant lipid that inhibits the enzyme when it is bound to either phospholipids or to factor Va |
755098 |
| 3.4.21.6 | down |
the gene expression of factor X in retinal pigment epithelial cells is decreased by blood serum, activated factor X, thrombin, transforming growth factor beta1, and platelet-derived growth factor |
731958 |
| 3.4.21.6 | up |
diabetes mellitus increases urinary enzyme activity in glomerular macrophages |
752614 |
| 3.4.21.6 | up |
enzyme protein levels increase 1 h after injury of the peripheral nerve and then decrease significantly at 1 and 2 days following injury |
754909 |
| 3.4.21.6 | up |
the gene expression of factor X in retinal pigment epithelial cells is increased by hypoxia and prostaglandin E2 |
731958 |
