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Literature summary for 3.4.21.6 extracted from

  • Hollborn, M.; Kohen, L.; Werschnik, C.; Tietz, L.; Wiedemann, P.; Bringmann, A.
    Activated blood coagulation factor X (FXa) induces angiogenic growth factor expression in human retinal pigment epithelial cells (2012), Invest. Ophthalmol. Vis. Sci., 53, 5930-5939.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens
-
 trhombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Homo sapiens trhombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
FXa
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the gene expression of factor X in retinal pigment epithelial cells is decreased by blood serum, activated factor X, thrombin, transforming growth factor beta1, and platelet-derived growth factor down
Homo sapiens the gene expression of factor X in retinal pigment epithelial cells is increased by hypoxia and prostaglandin E2 up

General Information

General Information Comment Organism
physiological function activated blood coagulation factor X (FXa) induces angiogenic growth factor expression in human retinal pigment epithelial (RPE) cells. FXa induced chemotaxis of RPE cells via activation of the p38 mitogen-activated protein kinase signal transduction pathway. FXa also induces expression of vascular endothelial growth factor, heparin-binding epidermal growth factor-like growth factor, and basic fibroblast growth factor, as well as release of these factors from RPE cells Homo sapiens