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Literature summary for 3.4.21.6 extracted from

  • Oe, Y.; Hayashi, S.; Fushima, T.; Sato, E.; Kisu, K.; Sato, H.; Ito, S.; Takahashi, N.
    Coagulation factor Xa and protease-activated receptor 2 as novel therapeutic targets for diabetic nephropathy (2016), Arterioscler. Thromb. Vasc. Biol., 36, 1525-1533 .
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
edoxaban
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protease-activated receptor 1 + H2O Mus musculus
-
 activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 2 + H2O Mus musculus
-
 activated protease-activated receptor 2 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-
glomerular macrophage
-
 Mus musculus
-
urine
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protease-activated receptor 1 + H2O
-
 Mus musculus activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 2 + H2O
-
 Mus musculus activated protease-activated receptor 2 + ?
-
 ?

Synonyms

Synonyms Comment Organism
FXa
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus diabetes mellitus increases urinary enzyme activity in glomerular macrophages up

General Information

General Information Comment Organism
physiological function the enzyme induces inflammation by activating protease-activated receptor 1 and protease-activated receptor 2 Mus musculus