EC Number   |
Expression |
Reference |
|---|
   3.4.24.17 | up |
exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase-3 that mediates a morphological transformation of microglia into a multinucleated globoid cell type. But although psychosine treatment in primary purified microglial cultures moderately induces MMP-3 expression, treatment of peripheral blood or purified macrophages with equivalent concentrations of psychosine does not induce MMP-3 expression |
-, 733946 |
| 3.4.24.17 | up |
MMP-3 expression is upregulated with age, overview |
708594 |
| 3.4.24.17 | up |
MMP-3 is induced by interleukin-1beta, which, despite its effects on MMP-3 expression, fails to significantly alter invasion of SGHPL-4 cells through Matrigel-coated transwells |
710257 |
| 3.4.24.17 | up |
MMP-3 is induced in gingival fibroblasts in response to inflammatory cytokines, such as TNF and interleukin-1 |
709669 |
| 3.4.24.17 | up |
MMP-3 is upregulated after stroke in brain in the infarcted tissue compared to healthy control areas, overview |
709700 |
| 3.4.24.17 | up |
serum MMP-3 is significantly elevated in ankylosing spondylitis patients with active disease |
718392 |
| 3.4.24.17 | up |
the expression of the enzyme is upregulated in Dengue virus-infected RAW264.7 cells |
735131 |
| 3.4.24.17 | up |
TNF-alpha and IL-1beta stimulate production of MMPs through the activation of mitogen-activated protein kinases, NF-kappaB and AP-1 |
709685 |
| 3.4.24.17 | up |
TNF-alpha and interleukin-1beta act synergistically to drive MMP-3 secretion. NF-kappaB and AP-1 c-Jun/FosB heterodimers regulate CoMTb-induced MMP-3 secretion. NF-kappaB p65 and AP-1 c-Jun subunits are upregulated in biopsy granulomas from patients with cerebral tuberculosis. CoMTb upregulates MMP-3 gene expression and secretion in microglia |
709370 |
