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Literature summary for 3.4.24.17 extracted from

  • Mun, S.H.; Kim, H.S.; Kim, J.W.; Ko, N.Y.; Kim, D.K.; Lee, B.Y.; Kim, B.; Won, H.S.; Shin, H.S.; Han, J.W.; Lee, H.Y.; Kim, Y.M.; Choi, W.S.
    Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway (2009), J. Pharmacol. Sci., 111, 13-21.
    View publication on PubMed
Search for more literature for 3.4.24.17

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Mus musculus
-
-
extracellular the enzyme is secreted Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 DBA/1J mice
-
Mus musculus DBA/1J
-
 DBA/1J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
 Homo sapiens
-
chondrocyte
-
 Homo sapiens
-
paw collagen-induced arthritis hind paw sections as a model of human rheumatoid arthritis Mus musculus
-
SW-1353 cell a human chondrosarcoma cell line Homo sapiens
-
synovial tissue
-
 Homo sapiens
-
synoviocyte fibroblast-like, from rheumatoid arthritis patients Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-3
-
 Mus musculus
matrix metalloproteinase-3
-
 Homo sapiens
MMP-3
-
 Mus musculus
MMP-3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of MMP-3 in cartilages and synovial tissues is suppressed by the treatment of curcumin and indomethacin. Production of MMP-3 is inhibited by curcumin in tumor necrosis factor-alpha-stimulated rheumatoid arthritis fibroblast-like synoviocytes and chondrocytes in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview down
Mus musculus production of MMP-3 is inhibited by curcumin in collagen-induced arthritis hind paw sections in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview down
Homo sapiens TNF-alpha and IL-1beta stimulate production of MMPs through the activation of mitogen-activated protein kinases, NF-kappaB and AP-1 up