3.4.24.17	down	Curcumin dose dependently suppresses MMP-3 and -9 expression in Helicobacter pylori infected human gastric epithelial cells	718271	
3.4.24.17	down	Curcumin dose dependently suppresses MMP-3 and -9 expression in Helicobacter pylori infected mouse gastric tissues	718271	
3.4.24.17	down	dexamethasone suppression of MMP-3 gene expression	709370	
3.4.24.17	down	expression of MMP-3 in cartilages and synovial tissues is suppressed by the treatment of curcumin and indomethacin. Production of MMP-3 is inhibited by curcumin in tumor necrosis factor-alpha-stimulated rheumatoid arthritis fibroblast-like synoviocytes and chondrocytes in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview	709685	
3.4.24.17	down	glycitein, i.e. 4',7-dihydroxy-6-methoxyisoflavone, a bacterial metabolite of the isoflavone glycitin, downregulates MMP-3 gene expression by inhibiting the promoter activity of MMP-3	708089	
3.4.24.17	down	interleukin-1Ra, dexamethasone, and TNF significantly decrease levels of all forms of MMP-3	707312	
3.4.24.17	down	production of MMP-3 is inhibited by curcumin in collagen-induced arthritis hind paw sections in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview	-, 709685	
3.4.24.17	down	reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia	710257	
3.4.24.17	down	stromelysin-1 is slightly downregulated in obese adipose tissue compared to non-obese adipose tissue. Expression of MMP-3 mRNA in subcutaneous and gonadal adipose tissue is affected and 3.0-3.7fold reduced by MMP-10 deficiency, but vessel size is not affected	707379	
3.4.24.17	additional information	lipopolysaccharide does not induce mmp-3 mRNA expression in peripheral blood samples	-, 733946	
3.4.24.17	up	exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase-3 that mediates a morphological transformation of microglia into a multinucleated globoid cell type. But although psychosine treatment in primary purified microglial cultures moderately induces MMP-3 expression, treatment of peripheral blood or purified macrophages with equivalent concentrations of psychosine does not induce MMP-3 expression	-, 733946	
3.4.24.17	up	MMP-3 expression is upregulated with age, overview	708594	
3.4.24.17	up	MMP-3 is induced by interleukin-1beta, which, despite its effects on MMP-3 expression, fails to significantly alter invasion of SGHPL-4 cells through Matrigel-coated transwells	710257	
3.4.24.17	up	MMP-3 is induced in gingival fibroblasts in response to inflammatory cytokines, such as TNF and interleukin-1	709669	
3.4.24.17	up	MMP-3 is upregulated after stroke in brain in the infarcted tissue compared to healthy control areas, overview	709700	
3.4.24.17	up	serum MMP-3 is significantly elevated in ankylosing spondylitis patients with active disease	718392	
3.4.24.17	up	the expression of the enzyme is upregulated in Dengue virus-infected RAW264.7 cells	735131	
3.4.24.17	up	TNF-alpha and IL-1beta stimulate production of MMPs through the activation of mitogen-activated protein kinases, NF-kappaB and AP-1	709685	
3.4.24.17	up	TNF-alpha and interleukin-1beta act synergistically to drive MMP-3 secretion. NF-kappaB and AP-1 c-Jun/FosB heterodimers regulate CoMTb-induced MMP-3 secretion. NF-kappaB p65 and AP-1 c-Jun subunits are upregulated in biopsy granulomas from patients with cerebral tuberculosis. CoMTb upregulates MMP-3 gene expression and secretion in microglia	709370