EC Number |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
---|
2.5.1.59 | 636545 |
Characterization of yeast geranylgeranyl transferase type I expressed in Escherichia coli |
Mol. Cell |
6 |
602-608 |
1996 |
Bos taurus |
- |
2.5.1.59 | 636545 |
Characterization of yeast geranylgeranyl transferase type I expressed in Escherichia coli |
Mol. Cell |
6 |
602-608 |
1996 |
Saccharomyces cerevisiae |
- |
2.5.1.59 | 636548 |
Chromatographic assay and peptide substrate characterization of partially purified farnesyl- and geranylgeranyltransferases from rat brain cytosol |
Arch. Biochem. Biophys. |
354 |
83-94 |
1998 |
Rattus norvegicus |
9633601 |
2.5.1.59 | 672214 |
Conversion of protein farnesyltransferase to a geranylgeranyltransferase |
Biochemistry |
45 |
9746-9755 |
2006 |
Homo sapiens |
16893176 |
2.5.1.59 | 658092 |
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes |
Biochemistry |
43 |
9000-9008 |
2004 |
Rattus norvegicus |
15248757 |
2.5.1.59 | 722188 |
Design, synthesis, and characterization of piperazinedione-based dual protein inhibitors for both farnesyltransferase and geranylgeranyltransferase-I |
Eur. J. Med. Chem. |
46 |
2264-2273 |
2011 |
Rattus norvegicus |
21440964 |
2.5.1.59 | 672535 |
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I |
Bioorg. Med. Chem. |
13 |
677-688 |
2005 |
Homo sapiens |
15653335 |
2.5.1.59 | 705040 |
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation |
J. Med. Chem. |
52 |
4210-4220 |
2009 |
Mammalia |
19537691 |
2.5.1.59 | 705040 |
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation |
J. Med. Chem. |
52 |
4210-4220 |
2009 |
Rattus norvegicus |
19537691 |
2.5.1.59 | 705670 |
Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis |
Mol. Cancer |
9 |
23 |
2010 |
Homo sapiens |
20113484 |