2.5.1.59 758655 Inhibiting fungal echinocandin resistance by small-molecule disruption of geranylgeranyltransferase type i activity Antimicrob. Agents Chemother. 64 e02046-19 2020 [Candida] glabrata http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791942&form=6&db=m 2.5.1.59 758655 Inhibiting fungal echinocandin resistance by small-molecule disruption of geranylgeranyltransferase type i activity Antimicrob. Agents Chemother. 64 e02046-19 2020 Candida parapsilosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791942&form=6&db=m 2.5.1.59 758655 Inhibiting fungal echinocandin resistance by small-molecule disruption of geranylgeranyltransferase type i activity Antimicrob. Agents Chemother. 64 e02046-19 2020 Candida tropicalis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791942&form=6&db=m 2.5.1.59 758655 Inhibiting fungal echinocandin resistance by small-molecule disruption of geranylgeranyltransferase type i activity Antimicrob. Agents Chemother. 64 e02046-19 2020 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791942&form=6&db=m 2.5.1.59 758828 Protein farnesyltransferase catalyzes unanticipated farnesylation and geranylgeranylation of shortened target sequences Biochemistry 59 1149-1162 2020 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32125828&form=6&db=m 2.5.1.59 759142 Pyrazole-based potent inhibitors of GGT1 Synthesis, biological evaluation, and molecular docking studies Eur. J. Med. Chem. 124 666-676 2016 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27620969&form=6&db=m 2.5.1.59 636546 Active site determination of yeast geranylgeranyl protein transferase type I expressed in Escherichia coli Eur. J. Biochem. 265 105-111 1999 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10491163&form=6&db=m 2.5.1.59 660285 Characterisation of CaaX-prenyltransferases in Catharanthus roseus: relationships with the expression of genes involved in the early stages of monoterpenoid biosynthetic pathway Plant Sci. 168 1097-1107 2005 Catharanthus roseus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100125035&form=6&db=m 2.5.1.59 636542 Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I J. Biol. Chem. 272 10232-10239 1997 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9092572&form=6&db=m 2.5.1.59 636549 Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe Mol. Microbiol. 29 1357-1367 1998 Schizosaccharomyces pombe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9781874&form=6&db=m 2.5.1.59 636545 Characterization of yeast geranylgeranyl transferase type I expressed in Escherichia coli Mol. Cell 6 602-608 1996 Bos taurus - 2.5.1.59 636545 Characterization of yeast geranylgeranyl transferase type I expressed in Escherichia coli Mol. Cell 6 602-608 1996 Saccharomyces cerevisiae - 2.5.1.59 636548 Chromatographic assay and peptide substrate characterization of partially purified farnesyl- and geranylgeranyltransferases from rat brain cytosol Arch. Biochem. Biophys. 354 83-94 1998 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9633601&form=6&db=m 2.5.1.59 672214 Conversion of protein farnesyltransferase to a geranylgeranyltransferase Biochemistry 45 9746-9755 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16893176&form=6&db=m 2.5.1.59 658092 Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes Biochemistry 43 9000-9008 2004 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15248757&form=6&db=m 2.5.1.59 722188 Design, synthesis, and characterization of piperazinedione-based dual protein inhibitors for both farnesyltransferase and geranylgeranyltransferase-I Eur. J. Med. Chem. 46 2264-2273 2011 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21440964&form=6&db=m 2.5.1.59 672535 Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I Bioorg. Med. Chem. 13 677-688 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15653335&form=6&db=m 2.5.1.59 705040 Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation J. Med. Chem. 52 4210-4220 2009 Mammalia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19537691&form=6&db=m 2.5.1.59 705040 Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation J. Med. Chem. 52 4210-4220 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19537691&form=6&db=m 2.5.1.59 705670 Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis Mol. Cancer 9 23 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20113484&form=6&db=m 2.5.1.59 708819 Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork Invest. Ophthalmol. Vis. Sci. 49 2464-2471 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18316706&form=6&db=m 2.5.1.59 708819 Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork Invest. Ophthalmol. Vis. Sci. 49 2464-2471 2008 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18316706&form=6&db=m 2.5.1.59 738097 Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling Drug Discov. Today 20 267-276 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450772&form=6&db=m 2.5.1.59 738097 Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling Drug Discov. Today 20 267-276 2015 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450772&form=6&db=m 2.5.1.59 721258 Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle Am. J. Physiol. Lung Cell Mol. Physiol. 302 L420-L428 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160308&form=6&db=m 2.5.1.59 675067 Geranylgeranyltransferase I as a target for anti-cancer drugs J. Clin. Invest. 117 1223-1225 2007 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17476354&form=6&db=m 2.5.1.59 723166 Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells Mol. Brain 3 18 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20540740&form=6&db=m 2.5.1.59 738895 Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis J. Neurochem. 125 698-712 2013 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23534605&form=6&db=m 2.5.1.59 738895 Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis J. Neurochem. 125 698-712 2013 Rattus norvegicus Sprague-Dawley http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23534605&form=6&db=m 2.5.1.59 723013 Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation J. Mol. Neurosci. 49 130-139 2013 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23073905&form=6&db=m 2.5.1.59 674196 Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids J. Am. Chem. Soc. 128 2822-2835 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16506760&form=6&db=m 2.5.1.59 636541 Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I Biochem. J. 320 925-932 1996 Rattus norvegicus - 2.5.1.59 687811 Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds J. Biol. Chem. 283 9571-9579 2008 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230616&form=6&db=m 2.5.1.59 659363 Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium J. Biol. Chem. 279 30546-30553 2004 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15131129&form=6&db=m 2.5.1.59 636539 Mammalian protein geranylgeranyltransferase-I: Substrate specificity, kinetic mechanism, metal requirements, and affinity labeling Biochemistry 34 1344-1354 1995 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7827082&form=6&db=m 2.5.1.59 686092 Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces Chemistry 14 1392-1401 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18200641&form=6&db=m 2.5.1.59 686092 Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces Chemistry 14 1392-1401 2008 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18200641&form=6&db=m 2.5.1.59 636547 Mutational analysis of the beta-subunit of yeast geranylgeranyl transferase I Mol. Gen. Genet. 252 1-10 1996 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8804398&form=6&db=m 2.5.1.59 739426 Nanoformulation of geranylgeranyltransferase-I inhibitors for cancer therapy: liposomal encapsulation and pH-dependent delivery to cancer cells PLoS ONE 10 e0137595 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26352258&form=6&db=m 2.5.1.59 671996 Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity Biochemistry 44 15314-15324 2005 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16285735&form=6&db=m 2.5.1.59 739309 Prenylation is required for polar cell elongation, cell adhesion, and differentiation in Physcomitrella patens Plant J. 78 441-451 2014 Physcomitrium patens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24634995&form=6&db=m 2.5.1.59 636550 Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases Biochem. J. 333 497-504 1998 Rattus norvegicus - 2.5.1.59 672621 Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I Bioorg. Med. Chem. Lett. 17 2639-2642 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17314046&form=6&db=m 2.5.1.59 636540 Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I J. Biol. Chem. 269 23465-23470 1994 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8089111&form=6&db=m 2.5.1.59 660261 Protein geranylgeranyltransferase I is involved in specific aspects of abscisic acid and auxin signaling in Arabidopsis Plant Physiol. 139 722-733 2005 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183844&form=6&db=m 2.5.1.59 688892 Protein geranylgeranyltransferase-I of Trypanosoma cruzi Mol. Biochem. Parasitol. 157 32-43 2008 Trypanosoma cruzi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996962&form=6&db=m 2.5.1.59 689979 Protein prenylation in an insect cell-free protein synthesis system and identification of products by mass spectrometry Proteomics 7 1942-1950 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17514686&form=6&db=m 2.5.1.59 636537 Protein prenyltransferases J. Biol. Chem. 271 5289-5292 1996 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621375&form=6&db=m 2.5.1.59 658829 Protein prenyltransferases Genome Biol. 4 212 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702202&form=6&db=m 2.5.1.59 689526 Proteins prenylated by type I protein geranylgeranyltransferase act positively on the jasmonate signalling pathway triggering the biosynthesis of monoterpene indole alkaloids in Catharanthus roseus Plant Cell Rep. 28 83-93 2009 Catharanthus roseus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18813931&form=6&db=m 2.5.1.59 636538 Purification of a mammalian protein geranylgeranyltransferase. Formation and catalytic properties of an enzyme-geranylgeranyl pyrophosphate complex J. Biol. Chem. 268 4055-4060 1993 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8440698&form=6&db=m 2.5.1.59 738142 Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence Eukaryot. Cell 12 1462-1471 2013 Cryptococcus neoformans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24014765&form=6&db=m 2.5.1.59 674210 Small-molecule inhibitors of protein geranylgeranyltransferase type I J. Am. Chem. Soc. 129 5843-5845 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17439124&form=6&db=m 2.5.1.59 658547 Structure of mammalian protein geranylgeranyltransferase type-I EMBO J. 22 5963-5974 2003 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14609943&form=6&db=m 2.5.1.59 687774 Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate J. Biol. Chem. 283 31933-31940 2008 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18713740&form=6&db=m 2.5.1.59 737695 Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition Biochemistry 53 434-446 2014 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24344934&form=6&db=m 2.5.1.59 739114 The role of geranylgeranyltransferase I-mediated protein prenylation in the brain Mol. Neurobiol. 53 6925-6937 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26666664&form=6&db=m 2.5.1.59 739114 The role of geranylgeranyltransferase I-mediated protein prenylation in the brain Mol. Neurobiol. 53 6925-6937 2015 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26666664&form=6&db=m 2.5.1.59 739114 The role of geranylgeranyltransferase I-mediated protein prenylation in the brain Mol. Neurobiol. 53 6925-6937 2015 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26666664&form=6&db=m 2.5.1.59 675272 Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I J. Lipid Res. 47 681-699 2006 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16477080&form=6&db=m 2.5.1.59 671997 Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I Biochemistry 44 15325-15333 2005 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16285736&form=6&db=m 2.5.1.59 636543 Yeast protein geranylgeranyltransferase type-I: overproduction, purification, and characterization Arch. Biochem. Biophys. 321 182-190 1995 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7639519&form=6&db=m 2.5.1.59 636544 Yeast protein geranylgeranyltransferase type-I: steady-state kinetics and substrate binding Biochemistry 36 4552-4557 1997 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109664&form=6&db=m