EC Number |
Posttranslational Modification |
Reference |
---|
3.4.24.B10 | glycoprotein |
degylcosylation with endoglycosidase H |
651920 |
3.4.24.B10 | phosphoprotein |
c-Src kinase activity regulates ADAM12-L phosphorylation (tyrosine phosphorylation) and the c-Src-ADAM12-L interaction, the cytoplasmic tail of ADAM12-L has two Src SH3-binding sites, the high-affinity c-Src binding site is important for its cellular localization with c-Src to actin-rich structures at the cell periphery |
711938 |
3.4.24.B10 | proteolytic modification |
- |
653221 |
3.4.24.B10 | proteolytic modification |
autocleavage occurs near the junction of the prodomain and the catalytic domain upon inactivation of cysteine residues C179 and in presence of Cu2+ which is further promoted in presence of ascorbate, multistep activation mechanism involving both furin cleavage and copper binding |
651290 |
3.4.24.B10 | proteolytic modification |
the cysteine-switch of the prodomain maintaines the zymogen in a latent state, enzyme is synthesized as a catalytically inactive zymogen, in vivo cleavage by a furin-like endopeptidase, activation is chemically possible with N-ethylmaleimide, but not with Hg2+ |
651886 |
3.4.24.B10 | proteolytic modification |
the cysteine-switch of the prodomain maintaines the zymogen in a latent state, enzyme is synthesized as a catalytically inactive zymogen, in vivo cleavage by a furin-like endopeptidase, autoactivation is possible with N-ethylmaleimide |
651920 |