EC Number   |
Application |
Reference |
|---|
    4.6.1.1 | analysis |
development of a fluorescence resonance energy transfer (FRET) sensor that functions both as a soluble cyclase and a reporter of complementation within the catalytic domain. There is a strong linear correlation between catalytic domain complementation and cyclase activity upon stimulation with forskolin and the Galphas subunit. The sensor is functional in live cells |
748698 |
| 4.6.1.1 | analysis |
technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression |
-, 682112 |
| 4.6.1.1 | analysis |
the enzyme activity is useful as a marker for determination of G-protein-coupled receptor function mediating adenylyl cylcase activation by extracellular baculovirus particles, usage of this budded virus display system to detect G-protein-coupled receptor signaling, method development, overview |
693293 |
| 4.6.1.1 | drug development |
AC1 is a potential drug target site to improve long-term remote memor |
693750 |
| 4.6.1.1 | drug development |
CyaA substantially contributes to the pathogenesis of whooping cough, catalytic site of CyaA possesses substantial conformational freedom to accommodate structurally diverse ligands, certain ligands bind to CyaA even in the absence of calmodulin, facilitating future inhibitor design |
682024 |
| 4.6.1.1 | drug development |
stable AC2-expressing CHODUKX cell line in which the generation of high expressing GPCR receptor/AC2 lines can retain their functional responsiveness and can provide pharmacological drug comparisons between the same host line for screening purposes and measurement of multiple cellular parameters |
681587 |
| 4.6.1.1 | medicine |
A2bR mediates signaling through AC-6 isoform, therapeutic implications for intestinal inflammation or diarrhea wherein A2bR is upregulated |
678381 |
| 4.6.1.1 | medicine |
AC1 and AC8 involved in long-term memory and in N-methyl-D-aspartate-dependent long-term potentiation, AC1 and AC8 are not required for acute pain response. AC1 is the major Ca2+ sensor for N-methyl-D-aspartate receptor activation and excitotoxicity |
681976 |
| 4.6.1.1 | medicine |
AC5 is the major AC isoform mediating acute beta-adrenergic stimulation, AC5 plays a major role in L-type Ca2+ currents activation |
-, 681577 |
| 4.6.1.1 | medicine |
AC6 improves function in Galphaq-hypertrophic pigs |
679659 |
