EC Number   |
Application |
Reference |
|---|
    4.1.1.50 | agriculture |
incubation of the cut flower with water increases both enzyme activity and spermine content 2fold, which are followed by ethylene production. Reaction may be a resistance mechanism against fungal and bacterial infection. Overexpression of enzyme may be a tool to improve rose cultivars for the common usage |
680076 |
| 4.1.1.50 | analysis |
development of a simple, economic, and non-radioactive spectrometric enzymatic assay, which can be adapted for experimental high-throughput screening of AdoMetDC inhibitors |
749303 |
| 4.1.1.50 | biotechnology |
overexpression of enzyme is sufficient for accumulation of spermidine in leaves and spermidine and spermine in seeds |
653529 |
| 4.1.1.50 | medicine |
adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase in lung cancer cell line A-549. Antisense enzyme expression inhibits tumor cell growth through blocking the polyamine synthesis pathway. Tumor cells are arrested at G1 phase and invasivness is reduced |
677292 |
| 4.1.1.50 | medicine |
enzyme inhibitor (2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide, i.e. CGP48664A, SAM486A, suppresses HIV-1 replication, including the replication of viruses that are resistant to multiple reverse transcriptase and protease inhibitos. Antiretroviral effect is based on the fact that regulatory protein Rev activity is severely compromised in drug-treated cells. No toxic effects on cellular metabolism are observed |
681225 |
| 4.1.1.50 | medicine |
essential role of enzyme in embryonic development, polyamines are required for cell proliferation after E3.5 |
651416 |
| 4.1.1.50 | medicine |
S-adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target, inhibition of the enzyme by methylglyoxal bis(guanylhydrazone) prevents HSV-1 infection |
664878 |
| 4.1.1.50 | pharmacology |
potential target for therapeutic agents against various parasitic diseases and proliferating disorders |
4699 |
| 4.1.1.50 | pharmacology |
potentially important drug target for the chemotherapy of proliferative and parasitic diseases |
4685 |
| 4.1.1.50 | pharmacology |
potentially important target for chemotherapy of filiarial infection |
4687 |
