Literature summary for 4.1.1.50 extracted from

Nishimura, K.; Nakatsu, F.; Kashiwagi, K.; Ohno, H.; Saito, T.; Igarashi, K.
Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development (2002), Genes Cells, 7, 41-47.

Search for more literature for 4.1.1.50

Application

Application	Comment	Organism
medicine	essential role of enzyme in embryonic development, polyamines are required for cell proliferation after E3.5	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	targeted disruption of enzyme gene, heterozygous animals were viable, normal and fertile, homozygous embryos died early in embryonic development, homozygous blastocysts at E3.5 arrested cell proliferation which was rescued by addition of spermidine	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	enzyme is essential for embryonic development	-

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Release 2023.1 (January 2023)