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Literature summary for 4.1.1.50 extracted from

  • Liao, C.; Wang, Y.; Tan, X.; Sun, L.; Liu, S.
    Discovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay (2015), Sci. Rep., 5, 10754 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
analysis development of a simple, economic, and non-radioactive spectrometric enzymatic assay, which can be adapted for experimental high-throughput screening of AdoMetDC inhibitors Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
docking of inhibitor 2-amino-3-[(E)-(2-fluorophenyl)diazenyl]-4,5,6,7-tetrahydro-8H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-one, compound binds the enzyme with interactions similar to known inhibitors. The major interactions are the ring-ring stacking interactions with Phe7 and Phe223, the polar interactions with the side-chain or main-chain atoms of Leu65, Ser68, Glu67, Asn224, and Cys226 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-amino-3-[(E)-(2-fluorophenyl)diazenyl]-4,5,6,7-tetrahydro-8H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-one compound shows comparable inhibitory effects as methylglyoxal bis(guanylhydrazone) Homo sapiens
methylglyoxal bis(guanylhydrazone)
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0031
-
S-adenosyl-L-methionine pH not specified in the publication, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl 3-(methylthio)propylamine + CO2
-
?

Synonyms

Synonyms Comment Organism
AdoMetDC
-
Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
20
-
S-adenosyl-L-methionine pH not specified in the publication, 37°C Homo sapiens