Application | Comment | Organism |
---|---|---|
analysis | development of a simple, economic, and non-radioactive spectrometric enzymatic assay, which can be adapted for experimental high-throughput screening of AdoMetDC inhibitors | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
docking of inhibitor 2-amino-3-[(E)-(2-fluorophenyl)diazenyl]-4,5,6,7-tetrahydro-8H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-one, compound binds the enzyme with interactions similar to known inhibitors. The major interactions are the ring-ring stacking interactions with Phe7 and Phe223, the polar interactions with the side-chain or main-chain atoms of Leu65, Ser68, Glu67, Asn224, and Cys226 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-3-[(E)-(2-fluorophenyl)diazenyl]-4,5,6,7-tetrahydro-8H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-one | compound shows comparable inhibitory effects as methylglyoxal bis(guanylhydrazone) | Homo sapiens | |
methylglyoxal bis(guanylhydrazone) | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0031 | - |
S-adenosyl-L-methionine | pH not specified in the publication, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens | S-adenosyl 3-(methylthio)propylamine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AdoMetDC | - |
Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
20 | - |
S-adenosyl-L-methionine | pH not specified in the publication, 37°C | Homo sapiens |