EC Number   |
Application |
Reference |
|---|
   3.6.5.2 | analysis |
nucleotide exchange kinetics with small GTPases can be used to obtain important information about the binding kinetics of GTP molecules under different activation states and with different activator molecules |
733077 |
| 3.6.5.2 | drug development |
the enzyme Der may be an ideal cellular target against which antibiotics can be developed, lead compounds inhibiting Der GTPase provide scaffolds for the development of antibiotics against antibiotic-resistant pathogenic bacteria |
734036 |
| 3.6.5.2 | medicine |
neither the overall survival nor the disease-free survival rate in diffuse large B-cell lymphoma can be linked to hypermutation of the RHOH gene |
697169 |
| 3.6.5.2 | medicine |
potential target for cancer therapeutics |
657767 |
| 3.6.5.2 | medicine |
Rab27a is associated with the Griscelli syndrome type 2, mutations in the Rab27a gene cause pigment as well as cytotoxic granule transport defects, accounting for the partial albinism and severe immune disorder characteristics of this syndrome |
658342 |
| 3.6.5.2 | medicine |
regulation of small Rho GTPases might serve as a new pharmacological tool for protection of dendridic cell vaccines from tumor-induced inhibition and functional failure |
688152 |
| 3.6.5.2 | medicine |
small Rho GTPases might serve as new targets for modulating functional activity of dendritic cell vaccines or endogenous dendritic cells in various immunotherapeutic or chemoimmunotherapeutic strategies |
688162 |
| 3.6.5.2 | pharmacology |
the enzyme is a pharmacological target for the treatment of cardiovascular diseases |
734348 |
