EC Number   |
Application |
Reference  |
|---|
   3.4.21.B12 | medicine |
enzyme might be useful as diagnostic marker in ovarian cancer |
647332 |
| 3.4.21.B12 | medicine |
tumor-associated overexpression of tissue kallikreins contributes to ovarian cancer progression. OV-MZ-6 ovarian cancer cells simultaneously expressing K4-7 display similar proliferative capacity as the vector-transfected control cells, but show significantly increased invasive behavior. Simultaneous expression of K4-7 in OV-MZ-6 cells and inoculated into the peritoneum of nude mice, results in a remarkable 92% mean increase in tumor burden compared to control cell line |
664273 |
| 3.4.21.B12 | medicine |
patients with epithelial ovarian carcinoma, carcinoma cells expressed enzyme in 80% of effusions and 82% of solid tumors, levels are highest in effusions. Enzyme expression does not predict survival |
667120 |
| 3.4.21.B12 | analysis |
enzyme-specific sandwich-type immunoassay using a monoclonal antibody, detection limit is 0.02 microgram per liter, and less than 0.1% cross-reactivity with other human kallikreins |
668285 |
| 3.4.21.B12 | medicine |
no significant differences in enzyme protein content between healthy prostate tissue and malignant or benign prostate |
668285 |
| 3.4.21.B12 | medicine |
naturally occuring gene mutation G214A results in a truncated enzyme that lacks residue S207 of the catalytic triad. Mutation affects tooth enamel formation causing the enamel crystallites to grow incompletely in thickness or width but to normal length, i.e. autosomal recessive hypomaturation amelogenesis imperfecta |
669814 |
| 3.4.21.B12 | medicine |
expression of the various tissue kallikreins like KLK4 in the endometrium and conceptus during the estrous cycle and early pregnancy in the pig can serve in the activation of growth factors and tissue remodeling during the establishment of pregnancy |
682813 |
| 3.4.21.B12 | medicine |
KLK4 is a proliferative factor with effects on cell cycle-related gene expression. It may have an important role in prostate cancer development and progression |
685946 |
| 3.4.21.B12 | medicine |
KLK-4 proteinase is essential for the final crystallite growth of enamel but is not critical for crystallite orientation, prism formation or enamel thickness |
686543 |
| 3.4.21.B12 | medicine |
KLK4 initiates Ca2+ mobilization via PAR-1 and PAR-2 but not via PAR-4. KLK4 has greater efficacy for initiating Ca2+ signalling via PAR-2 than PAR-1. Signals induced by KLK4 via PARs may be important in prostate cancer |
687699 |
