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Literature summary for 3.4.21.B12 extracted from

  • Klokk, T.I.; Kilander, A.; Xi, Z.; Waehre, H.; Risberg, B.; Danielsen, H.E.; Saatcioglu, F.
    Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer (2007), Cancer Res., 67, 5221-5230.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
doxycycline
-
Homo sapiens

Application

Application Comment Organism
medicine KLK4 is a proliferative factor with effects on cell cycle-related gene expression. It may have an important role in prostate cancer development and progression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
adenovirus-mediated ectopic expression of KLK4 in PC-3 cells and DU145 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA mediates knockdown of endogenous KLK4 in LNCaP prostate cancer cells whereby inhibiting their proliferation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
nucleus is predominantely nuclear in normal prostate epithelial cells Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
Homo sapiens
-
prostate cell line KLK4 protein is significantly overexpressed in malignant prostate compared with normal prostate. No significant differences in expression levels among well or poorly differentiated tumors Homo sapiens
-

Synonyms

Synonyms Comment Organism
kallikrein 4
-
Homo sapiens
KLK4
-
Homo sapiens