Activating Compound | Comment | Organism | Structure |
---|---|---|---|
doxycycline | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | KLK4 is a proliferative factor with effects on cell cycle-related gene expression. It may have an important role in prostate cancer development and progression | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
adenovirus-mediated ectopic expression of KLK4 in PC-3 cells and DU145 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | mediates knockdown of endogenous KLK4 in LNCaP prostate cancer cells whereby inhibiting their proliferation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
nucleus | is predominantely nuclear in normal prostate epithelial cells | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | - |
Homo sapiens | - |
prostate cell line | KLK4 protein is significantly overexpressed in malignant prostate compared with normal prostate. No significant differences in expression levels among well or poorly differentiated tumors | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
kallikrein 4 | - |
Homo sapiens |
KLK4 | - |
Homo sapiens |