EC Number   |
Application |
Reference  |
|---|
   3.4.21.110 | medicine |
inactivates recombinant chemotaxin C5a by destroying its capacity to interact with the C5a receptor on human polymorphonuclear leukocytes |
671820 |
| 3.4.21.110 | medicine |
acts as a potential invasin of group A streptococcus and promotes invasion independent of fibronectin |
673973 |
| 3.4.21.110 | medicine |
SCPA is highly immunogenic in children infected with group A streptococcal pharyngitis |
673974 |
| 3.4.21.110 | medicine |
intranasal immunization with SCPA prevents colonization and infection of human tonsils, thereby eliminating potential reservoirs that maintain endemic disease |
673982 |
| 3.4.21.110 | more |
ScpA and the multifunctional protein streptococcal plasmin receptor/surface dehydrogenase/glyceraldehyde-3-phosphate dehydrogenase are both necessary for the cleavage of C5a on the bacterial surface |
-, 674559 |
| 3.4.21.110 | more |
streptococcal C5a peptidase binding to integrins by the Arg-Gly-Asp motifs may stabilize conformational changes required for substrate binding |
676783 |
| 3.4.21.110 | more |
greatly reduces ability to bind to receptors of polymorphonuclear leukocytes as compared with native C5a, inactivation is temperature dependent, mediates a small decrease in the molecular weight of C5adesArg and a six-residue peptide in inactivated C5a is lost |
676910 |
| 3.4.21.110 | medicine |
immunization with C5a peptidase protein from either group A or group B streptococci provides protection against group A streptococcus infections in mice, moreover, mice immunized with antibodies directed against protein from group B streptococci also cleared streptococci from their lungs more efficiently than those immunized with tetanus toxoid |
677242 |
| 3.4.21.110 | medicine |
encapsulated C5a peptidase elicites significant immune responses and protection against group B streptococci challenge. C5a peptidase microsphere encapsulation has potential as a group B streptococci vaccine |
684315 |
| 3.4.21.110 | medicine |
fibronectin adhesin activity of scpB plays a role in virulence |
-, 687071 |
