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Literature summary for 3.4.21.110 extracted from

  • Park, H.S.; Cleary, P.P.
    Active and passive intranasal immunizations with streptococcal surface protein C5a peptidase prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils (2005), Infect. Immun., 73, 7878-7886.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine intranasal immunization with SCPA prevents colonization and infection of human tonsils, thereby eliminating potential reservoirs that maintain endemic disease Streptococcus sp.

Cloned(Commentary)

Cloned (Comment) Organism
strain 90 226 SCPA-mutant expressed in Escherichia coli Streptococcus sp.

Protein Variants

Protein Variants Comment Organism
D130A strain 90 226 SCPA-mutant, impaired capacity to infect nasal mucosa-associated lymphoid tissue Streptococcus sp.

Inhibitors

Inhibitors Comment Organism Structure
anti-ScpA antibody reduces group A streptococci colonization of nasal mucosa-associated lymphoid tissue administered alone or with cholera toxin Streptococcus sp.
anti-SCPB antibody also provides protection against group A streptococcal infection Streptococcus sp.
additional information a high degree of group A streptococci colonization of nasal mucosa-associated lymphoid tissue in control mice immunized with phosphate-buffered saline only Streptococcus sp.

Organism

Organism UniProt Comment Textmining
Streptococcus sp.
-
 group A Streptococcus strain 90 226 serotype M1, strain Xen-20 serotype M49
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
SCPA
-
 Streptococcus sp.
surface-bound C5a peptidase
-
 Streptococcus sp.