EC Number   |
Application |
Reference |
|---|
    3.1.3.5 | medicine |
CD73 may facilitate the adhesion, migration, and invasion of human breast cancer cells through its enzyme activity of generating adenosine |
693298 |
| 3.1.3.5 | medicine |
CD73 plays a role in attenuating intestinal ischemia-reperfusion-mediated injury |
692272 |
| 3.1.3.5 | medicine |
CD73 plays an important role in adenosine generation in the liver, the extracellular adenosine generated by CD73 is a critical mediator of hepatic fibrosis |
692268 |
| 3.1.3.5 | medicine |
determination of 5'-nucleotidase activity, especially in spermatozoa, can be useful to characterize different varicocele degrees and the sperm fertility potential |
693385 |
| 3.1.3.5 | medicine |
ecto-5'-nucleotidase is a marker of ER (-) breast carcinoma and elevated expression correlates with invasive mesenchymal cell phenotype |
691078 |
| 3.1.3.5 | medicine |
hepatic ischemia/reperfusion is associated with a significant induction of ecto-5'-nucleotidase transcript and protein, use of soluble ecto-5'-nucleotidase may be a potential therapeutic for hepatic ischemia |
692462 |
| 3.1.3.5 | medicine |
in liver of merosin-deficient dystrophic Lama2dy mice, enzyme level is 77% elevated compared to control. Liver of dystrophic animals contains active and inactive enzyme variants |
665213 |
| 3.1.3.5 | medicine |
in neonatal blood plasma, soluble 5'-nucleotidase and alkaline phosphatase mediate conversion of AMP to adenosine, whereas soluble adenosine deaminase catabolizes adenosine to inosine. Newborn blood plasma demonstrates substantially higher adenosine-generating 5'-nucleotidase and alkaline phosphatase activity and lower metabolizing adenosine deaminase activity than adult plasma. Supplementation with AMP inhibits whereas selective pharmacologic inhibition of 5'-nucleotidase enhances Toll-like receptor-mediated tumor necrosis factor TNF-alpha production in neonatal whole blood |
730020 |
| 3.1.3.5 | medicine |
in normal and AMP deaminase-deficient skeletal muscle, there are no significant differences between different enzyme sources in the activities of ecto- and cytosolic 5'-nucleotidase isoform, and no gender-specific difference. A weak inverse correlation is found between AMP deaminase activity and cytosolic enzyme activity |
664271 |
| 3.1.3.5 | medicine |
in patients with acute lymphoblastic leukemia, enzyme activity decreases during 6-mercaptopurine treatment to about 50% of initial activity. After 6 weeks of treatment, there is a significant negative correlation between thio-GMP levels and enzyme activity |
664632 |
