Application | Comment | Organism |
---|---|---|
medicine | in patients with acute lymphoblastic leukemia, enzyme activity decreases during 6-mercaptopurine treatment to about 50% of initial activity. After 6 weeks of treatment, there is a significant negative correlation between thio-GMP levels and enzyme activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no product inhibition by 6-thioguanosine | Homo sapiens | |
thio-IMP | substrate inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-AMP + H2O | - |
Homo sapiens | adenosine + phosphate | - |
? | |
5'-GMP + H2O | - |
Homo sapiens | guanosine + phosphate | - |
? | |
5'-IMP + H2O | - |
Homo sapiens | inosine + phosphate | - |
? | |
methylthio-IMP + H2O | - |
Homo sapiens | ? + phosphate | - |
? | |
thio-GMP + H2o | - |
Homo sapiens | 6-thioguanosine + phosphate | - |
? | |
thio-IMP + H2O | - |
Homo sapiens | 6-thioinosine + phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
substrate thio-IMP | Homo sapiens |
7.5 | - |
substrates IMP, methylthio-IMP | Homo sapiens |
8 | - |
substrate thio-GMP | Homo sapiens |
8.5 | - |
substrates GMP, AMP | Homo sapiens |