EC Number   |
Application |
Reference |
|---|
    2.1.1.17 | analysis |
development of A system that transports phosphatidylethanolamine to the mitochondria where it is methylated to phosphatidylcholine and phosphatidylcholine is transported back to other organelles and supports the growth of the mutants defective in phosphatidylcholine synthesis |
-, 733406 |
| 2.1.1.17 | analysis |
simple cell-free enzymatic assay that measures the transfer of tritiated methyl group(s) from S-[methyl-3H]adenosyl-L-methionine onto phosphatidylethanolamine using whole cell extracts as an enzyme source. The resulting methylated forms of phosphatidylethanolamine are hydrophobic and can be separated from water soluble S-[methyl-3H]adenosyl-L-methionine by organic extraction |
757524 |
| 2.1.1.17 | medicine |
a multiple isotopomer distribution analysis approach is presented, based on transfer of deuterated methyl groups to S-adenosylmethionine and subsequent sequential methylations of phosphatidylethanolamine, to quantify absolute flux rates through the PEMT pathway that are applicable to studies of liver dysfunction in clinical studies |
720177 |
| 2.1.1.17 | medicine |
animals with homozygous disruption of enzyme gene, develop severe steatosis when fed a diet deficient in choline. Animals have substantially diminished concentrations of docosahexaenoic acid and arachidonic acid in plasma |
662691 |
| 2.1.1.17 | medicine |
both low and high levels of global DNA methylation are associated with the risk of bladder cancer. This risk follows a nonlinear association with LINE-1 methylation which significantly increases among individuals homozygous for the major allele of five single-nucleotide polymorphisms located in the phosphatidylethanolamine N-methyltransferase gene |
733594 |
| 2.1.1.17 | medicine |
in Pemt-/- mice, treatment with vitamin E (0.5 g/kg) for 3 weeks improves very low-density lipoprotein-triglyceride secretion and normalizes cholesterol metabolism, but fails to reduce hepatic triglyceride content. Vitamin E treatment is able to reduce hepatic oxidative stress, inflammation and fibrosis. Pemt-/- mice fed a high-fat diet show abnormal ceramide metabolism, with elevation of ceramides and other sphingolipids and higher expression of mRNAs for acid ceramidase (Asah1) and ceramide kinase (Cerk) |
756104 |
| 2.1.1.17 | medicine |
inhibition of PEMT and/or reduction of intestinal sodium concentration may be helpful in attenuating liver damage and prolonging hepatic function in intrahepatic cholestasis |
718982 |
| 2.1.1.17 | medicine |
PEMT deficiency reduces the phosphatidylcholine/phosphatidylethanolamine ratio in the ER and induces ER stress,which sensitizes the mice to high-fat-induced steatohepatitis |
756074 |
