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Information on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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EC Tree
2.1.1.17 phosphatidylethanolamine N-methyltransferaseSpecify your search results
Word Map
- 2.1.1.17
- phosphatidylcholine
- choline
- homocysteine
- cytidylyltransferase
- cdp-choline
- betaine
- s-adenosylhomocysteine
-
ctp:phosphocholine
- cdp-diacylglycerol
- phosphatidyl-n,n-dimethylethanolamine
- phosphatidyl-n-monomethylethanolamine
-
choline-deficient
-
transmethylation
- n-methyltransferases
-
kennedy
- adomet
-
vance
- phosphatidylmonomethylethanolamine
- medicine
-
ptdcho
- analysis
- phosphatidyldimethylethanolamine
- mthfd1
-
remethylation
-
cholinephosphotransferase
-
adohcy
-
choline-supplemented
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
Synonyms
pemt, phosphatidylethanolamine n-methyltransferase, phosphatidylethanolamine methyltransferase, phospholipid n-methyltransferase, phosphatidylethanolamine-n-methyltransferase, pe n-mtase, pmtx1, pe-nmt, pmtx3, phosphatidylethanolamine-n-methylase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
lipid methyl transferase
-
-
-
-
LMTase
-
-
-
-
methyltransferase, phosphatidylethanolamine
-
-
-
-
PE N-MTase
-
-
-
-
PEMT
phosphatidylethanolamine methyltransferase
-
-
-
-
phosphatidylethanolamine N-methyltransferase
phosphatidylethanolamine-N-methylase
-
-
-
-
phosphatidylethanolamine-S-adenosylmethionine methyltransferase
-
-
-
-
phospholipid N-methyltransferase
PmtA
PmtX1
PmtX3
PEMT
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
37256-91-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamin
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
phospholipid substrates and products are the first to bind and the last to dissociate from the active site
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
ordered bi-bi mechanism
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
-
-
-
?
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, overview
-
-
?
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamin
-
-
-
-
?
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamin
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
phospholipid substrates and products are the first to bind and the last to dissociate from the active site
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
ordered bi-bi mechanism
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
expression of PEMT2 in CHO cells does not down-regulate, but rather enhance, the expression of CTP-phosphocholine cytidylyltransferase
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimers disease
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the transfer of a methyl group to monomethyl-N-phosphatidylcholine and dimethyl-N,N-phosphatidylcholine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
485167, 485168, 485169, 485170, 485171, 485174, 485179, 485180, 485181, 485183, 485184, 485186, 485188, 485189, 485191, 485192, 485195
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
transfer of three methyl groups to the amino head group of phosphatidylethanolamine
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the transfer of a methyl group to monomethyl-N-phosphatidylcholine and dimethyl-N,N-phosphatidylcholine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
methylation of phosphatidylethanolamine may play a role in very low density lipoprotein secretion
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
possible role of PEMT2 in the suppression of liver proliferation, and perhaps in hepatic carcinogenesis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
activation of phosphatidylethanolamine methylation at the level of gene expression may be the mechanism by which choline-deficient rats compensate for the lack of dietary choline
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 plays an important role in the regulation of hepatocyte cell division and as a liver tumor suppressor
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
inactivation of enzyme form PEMT2 may have a role in the regulation of non-neoplastic growth of liver
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 may have a role in the regulation of in vivo hepatoma and hepatocyte cell division as well as hepatocyte cell death by apoptosis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the transfer of a methyl group to monomethyl-N-phosphatidylcholine and dimethyl-N,N-phosphatidylcholine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the first-step methylation from phosphatidylethanolamine to phosphatidylcholine is rate-limiting
-
-
?
additional information
?
-
only reaction for de novo synthesis of choline in the body via methylation of phosphatidylethanolamine to form phosphatidylcholine
-
-
?
additional information
?
-
-
enzyme-mediated secretion of homocysteine correlates with the methyltransferase activity of the enzyme, independently of subcellular localization
-
-
?
additional information
?
-
-
phosphatidylethanolamine N-methyltransferase is the key enzyme for endogenous biosynthesis of phosphatidylcholine.
-
-
?
additional information
?
-
-
a striking gender-specific conservation of choline in female mice does not occur in male mice
-
-
?
additional information
?
-
-
physiological functions of phosphatidylcholine, mutational analysis, overview
-
-
?
additional information
additional information
-
-
Mdr2 (+/-) and Mdr2 (+/+) mice have similar S-adenosylmethionine levels at 0 and 7 days on methionine and choline deficient diet, Mdr2 (+/-) mice have significantly higher S-adenosylmethionine levels after 30 days on methionine and choline deficient diet (40.2 vs. 6.1 nmol/g).
S-adenosylhomocysteine levels are significantly lower in Mdr2 (+/-) compared to Mdr2 (+/+) mice at 0 days (33.4 vs. 41.9 nmol/g) and 7 days on methionine and choline deficient diet (16.0 vs. 42.9 nmol/g).
-
?
additional information
additional information
-
-
the total hepatic S-adenosylmethionine levels remain unchanged by ethanol consumption for 4 weeks
S-adenosylhomocysteine levels increase by ethanol consumption for 4 weeks. The S-adenosylmethionine:S-adenosylhomocysteine ratios are significantly lower in ethanol fed rats. Supplementation of betaine in the ethanol diet increases the hepatocellular S-adenosylmethionine:S-adenosylhomocysteine ratios to values that are statistically similar to those from rats fed the regular control diet. There is an significant inverse relationship between triglycerids and S-adenosylmethionine:S-adenosylhomocysteine ratio (r = - 0.36).
-
?
additional information
additional information
-
the total hepatic S-adenosylmethionine levels remain unchanged by ethanol consumption for 4 weeks
S-adenosylhomocysteine levels increase by ethanol consumption for 4 weeks. The S-adenosylmethionine:S-adenosylhomocysteine ratios are significantly lower in ethanol fed rats. Supplementation of betaine in the ethanol diet increases the hepatocellular S-adenosylmethionine:S-adenosylhomocysteine ratios to values that are statistically similar to those from rats fed the regular control diet. There is an significant inverse relationship between triglycerids and S-adenosylmethionine:S-adenosylhomocysteine ratio (r = - 0.36).
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, overview
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
expression of PEMT2 in CHO cells does not down-regulate, but rather enhance, the expression of CTP-phosphocholine cytidylyltransferase
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimers disease
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
methylation of phosphatidylethanolamine may play a role in very low density lipoprotein secretion
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
possible role of PEMT2 in the suppression of liver proliferation, and perhaps in hepatic carcinogenesis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
activation of phosphatidylethanolamine methylation at the level of gene expression may be the mechanism by which choline-deficient rats compensate for the lack of dietary choline
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 plays an important role in the regulation of hepatocyte cell division and as a liver tumor suppressor
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
inactivation of enzyme form PEMT2 may have a role in the regulation of non-neoplastic growth of liver
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 may have a role in the regulation of in vivo hepatoma and hepatocyte cell division as well as hepatocyte cell death by apoptosis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the first-step methylation from phosphatidylethanolamine to phosphatidylcholine is rate-limiting
-
-
?
additional information
?
-
only reaction for de novo synthesis of choline in the body via methylation of phosphatidylethanolamine to form phosphatidylcholine
-
-
?
additional information
?
-
-
enzyme-mediated secretion of homocysteine correlates with the methyltransferase activity of the enzyme, independently of subcellular localization
-
-
?
additional information
?
-
-
phosphatidylethanolamine N-methyltransferase is the key enzyme for endogenous biosynthesis of phosphatidylcholine.
-
-
?
additional information
?
-
-
a striking gender-specific conservation of choline in female mice does not occur in male mice
-
-
?
additional information
?
-
-
physiological functions of phosphatidylcholine, mutational analysis, overview
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mg2+
-
3-5 fold activation of formation of phosphatidylcholine and phosphatidyl N,N-dimethylethanolamine. Synthesis of phosphatidyl N-monomethylethanolamine is not affected
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
S-adenosylhomocysteine
-
competitive with respect to S-adenosylmethionine
additional information
-
phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site
-
additional information
-
phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site
-
additional information
-
the cell toxicity for Spodoptera frugiperda (SF-9) insect cells of the phosphatidylethanolamine N-methyltransferase preparation dissapears, when the phosphatidylethanolamine N-methyltransferase preparation is treated with 100 mg Bio-Beads SM-2 + 10 mg Butyl Toyopearl or 100 g Bio-Beads SM-2 + 10 mg CM Toyopearl.; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent Bio-Beads SM-2 decreases the phosphatidylethanolamine N-methyltransferase activity to: 24.1% with 50 mg and 28.6% with 100 mg. Addition of 1% Trition X-100 restores the activity to 90% in the experiment with 100 mg Bio-Beads SM-2.; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent Butyl Toyopearl decreases the phosphatidylethanolamine N-methyltransferase activity to: 0.2% with 10 mg; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent CM Toyopearl decreases the phosphatidylethanolamine N-methyltransferase activity to: 0.4% with 10 mg
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-methyl-4-phenylpyridinium
-
enhances activity. S-Adenosylmethionine hypermethylation can be involved in the etiology of Parkinsons disease and an increase of phospholipid methylation could be one of the mechanisms by which 1-methyl-4-phenyl-pyridinium causes parkinsonism
betaine
attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, the effect is enhanced by ethanol, which alone has no effect on expression levels of the enzyme, overview
ethanol
enhances the inducing and protecting effects of betaine on the enzyme, alone has only a slightly activating effect on the enzyme activity, overview
progesterone
-
physiological levels of progesterone activate PE-NMT and sphingomyelin synthase
additional information
17-beta-estradiol induces the enzyme in hepatocytes
-
additional information
17-beta-estradiol induces the enzyme in hepatocytes
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0019
S-adenosylmethionine
-
reaction with phosphatidyl-N-monomethylethanolamine
0.0036
S-adenosylmethionine
-
reaction with phosphatidylethanolamine
0.0039
S-adenosylmethionine
-
phosphatidyl-N,N-dimethylethanolamine
0.0136
S-adenosylmethionine
-
reaction with phosphatidyl-N,N-dimethylethanolamine
0.016
S-adenosylmethionine
-
reaction with phosphatidyl-N,N-dimethylethanolamine
0.022
S-adenosylmethionine
-
reaction with phosphatidyl-N-monomethylethanolamine
0.0397
S-adenosylmethionine
-
reaction with phosphatidyl-N-monomethylethanolamine
0.08
S-adenosylmethionine
-
with phosphatidyl-N-monomethylethanolamine as substrate
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0739
S-adenosylhomocysteine
-
reaction with phosphatidyl-N-dimethylethanolamine
0.0048
S-adenosyl-L-homocysteine
-
towards phosphatidyl-N,N-dimethylethanolamine
0.0049
S-adenosyl-L-homocysteine
-
reaction with phosphatidyl-N-monomethylethanolamine
0.0067
S-adenosyl-L-homocysteine
-
reaction with phosphatidyl-N,N-dimethylethanolamine
0.0087
S-adenosyl-L-homocysteine
-
towards phosphatidyl-N-monomethylethanolamine
0.0118
S-adenosyl-L-homocysteine
-
towards phosphatidylethanolamine
0.012
S-adenosyl-L-homocysteine
-
inhibition with respect to S-adenosylmethionine
0.138
S-adenosyl-L-homocysteine
-
reaction with phosphatidyl-N-monomethylethanolamine
0.17
S-adenosyl-L-homocysteine
-
inhibition with respect to phosphatidylethanolamine
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
phosphatidylethanolamine N-methyltransferase activity is significantly lower in Mdr2 (+/-) compared to Mdr2 (+/+) mice: 1.20 nmol/mg/min vs. 1.98 nmol/mg/min. After 7 days on methionine and choline deficient diet enzyme activity is: Mdr2 (+/-) = 1.31 nmol/mg/min vs. Mdr2 (+/+) = 1.96 nmol/mg/min. After 30 days on methionine and choline deficient diet enzyme activity is: Mdr2 (+/-) = 1.60 nmol/mg/min vs. Mdr2 (+/+) = 1.99 nmol/mg/min
additional information
-
the activity of phosphatidylethanolamine N-methyltransferase increases (58% higher on day 5, 72% higher on day 7) over 7 d following the injection of streptozotocin (injection of 60 mg/kg on day 0). Diabetes increases the phosphatidylethanolamine N-methyltransferase activity and abundance. Administration of all-trans-retinoic acid alone or in combination with streptozotocin has no effect on phosphatidylethanolamine N-methyltransferase activity. Phosphatidylethanolamine N-methyltransferase activity and abundance in the streptozotocin + insulin group is not significantly different from control values. The enzymatic activity of phosphatidylethanolamine N-methyltransferase is determined by measuring the incorporation of radiolabled methyl groups from S-adenosyl-L-[methyl-3H]methionine into phospholipids.
additional information
-
there is a significant positive linear relationship between phosphatidylethanolamine N-methyltransferase activity and S-adenosylmethionine:S-adenosylhomocysteine ratio (r = 0.45). There is a significant inverse relationship between phosphatidylethanolamine N-methyltransferase activity and triglycerids. The metabolic conversion of radiolabeled phosphatidylethanolamine to phosphatidylcholine over 3 h incubation period is taken as a measure of phosphatidylethanolamine N-methyltransferase.
additional information
there is a significant positive linear relationship between phosphatidylethanolamine N-methyltransferase activity and S-adenosylmethionine:S-adenosylhomocysteine ratio (r = 0.45). There is a significant inverse relationship between phosphatidylethanolamine N-methyltransferase activity and triglycerids. The metabolic conversion of radiolabeled phosphatidylethanolamine to phosphatidylcholine over 3 h incubation period is taken as a measure of phosphatidylethanolamine N-methyltransferase.
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
10
additional information
-
activity increases in nearly a linear fashion between pH 6.0 and 9.5
10
-
methylation of phosphatidylethanolamine, phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N-dimethylethanolamine