Literature summary for 2.1.1.17 extracted from

Gao, X.; van der Veen, J.N.; Vance, J.E.; Thiesen, A.; Vance, D.E.; Jacobs, R.L.
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress (2015), Biochim. Biophys. Acta, 1852, 2689-2699 .

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Application

Application	Comment	Organism
medicine	PEMT deficiency reduces the phosphatidylcholine/phosphatidylethanolamine ratio in the ER and induces ER stress,which sensitizes the mice to high-fat-induced steatohepatitis	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q61907	-	-

Synonyms

Synonyms	Comment	Organism
PEMT	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	In chow-fed Pemt-/- mice, the hepatic phosphatidylcholine/phosphatidylethanolamine ratio in the ER is lower than in Pemt+/+ mice, and levels of ER stress markers, CHOP and BIP, are higher without activation of the unfolded protein response. In livers of high-fat-diet-fed Pemt-/- mice the ER has a lower phosphatidylcholine/phosphatidylethanolamine ratio, and exhibits more ER stress and unfolded protein response activation. The unfolded protein response is repressed in McArdle cells expressing PEMT compared with those lacking PEMT	Mus musculus

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Release 2023.1 (January 2023)