EC Number   |
Natural Substrates |
|---|
    6.3.1.9 | more |
the trypanothione synthase also catalyzes the reaction of glutathionylspermidine synthase, EC 6.3.1.8 |
| 6.3.1.9 | more |
the bifunctional trypanothione synthetase-amidase catalyzes biosynthesis and hydrolysis of the glutathione-spermidine adduct trypanothione, the principal intracellular thiolredox metabolite in parasitic trypanosomatids |
| 6.3.1.9 | more |
in pathogenic trypanosomes, trypanothione synthetase catalyzes the synthesis of both glutathionylspermidine and trypanothione (bis(glutathionyl)spermidine). Trypanothione is synthesized from two molecules of GSH that are covalently bridged by a spermidine in two ATP-dependent reactions. The enzyme also shows trypanothione amidase activity catalyzed at a second distinct active site |
| 6.3.1.9 | more |
trypanothione synthetase synthesizes trypanothione from glutathione and spermidine |
| 6.3.1.9 | N1-glutathionylspermidine + glutathione + ATP |
step two |
| 6.3.1.9 | N8-glutathionylspermidine + glutathione + ATP |
step two |
| 6.3.1.9 | N8-glutathionylspermidine + glutathione + ATP |
step two, N8-glutathionylspermidine is the favoured substrate |
