EC Number   |
Natural Substrates |
|---|
    2.7.7.41 | CTP + phosphatidate |
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis |
| 2.7.7.41 | CTP + phosphatidate |
enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides |
| 2.7.7.41 | CTP + phosphatidate |
the activity is essential for all phospholipid biosynthesis in Escherichia coli |
| 2.7.7.41 | CTP + phosphatidate |
the enzyme produces key intermediates in phospholipid biosynthesis |
| 2.7.7.41 | CTP + phosphatidate |
involved in phospholipid synthesis |
| 2.7.7.41 | CTP + phosphatidate |
involved in the de novo biosynthesis of cardiolipin |
| 2.7.7.41 | CTP + phosphatidate |
involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways |
| 2.7.7.41 | CTP + phosphatidate |
isozyme CDS1 shows no particular substrate specificity, displaying similar activities for almost all substrates tested |
| 2.7.7.41 | CTP + phosphatidate |
isozyme CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid |
| 2.7.7.41 | dCTP + phosphatidate |
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme |
