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Information on EC 2.7.7.41 - phosphatidate cytidylyltransferase
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2.7.7.41 phosphatidate cytidylyltransferaseSpecify your search results
Word Map
- 2.7.7.41
- phospholipid
- phosphatidylinositol
- phosphatidylglycerol
- cardiolipin
- cds1
- liponucleotide
-
raetz
-
phosphatidyltransferase
-
diphosphate-diacylglycerol
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
cdp-diacylglycerol synthase, cdp-dg, phosphatidate cytidylyltransferase, tam41, cdp-dag synthase, tamm41, ctp:phosphatidate cytidylyltransferase, cdp-diglyceride synthetase, tbcds, cdp-dg synthase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CDP-DAG synthase
CDP-DG
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CDP-DG synthase
CDP-DG synthetase
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CDP-diacylglyceride synthetase
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CDP-diacylglycerol synthase
CDP-diglyceride pyrophosphorylase
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CDP-diglyceride synthetase
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CDPdiglyceride pyrophosphorylase
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CDS
CDS1
CDS2
CDS3
CdsA
CTP-diacylglycerol synthetase
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CTP:1,2-diacylglycerophosphate-cytidyl transferase
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CTP:phosphatidate cytidylyltransferase
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cytidine diphosphoglyceride pyrophosphorylase
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cytidylyltransferase, phosphatidate
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DAG synthetase
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phosphatidate cytidyltransferase
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phosphatidic acid cytidylyltransferase
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SJAG_00426
Tam41
TAMM41
Tb927.7.220
TbCDS
additional information
CDP-DAG synthase
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CDP-diacylglycerol synthase
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CDS
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additional information
two different enzymes termed Cds1 and Cds2 with different genetical localization and different expression pattern
additional information
two different enzymes termed Cds1 and Cds2 with different genetical localization and different expression pattern
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CTP + phosphatidate = diphosphate + CDP-diacylglycerol
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CTP + phosphatidate = diphosphate + CDP-diacylglycerol
ping-pong mechanism
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CTP + phosphatidate = diphosphate + CDP-diacylglycerol
sequential mechanism
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CTP + phosphatidate = diphosphate + CDP-diacylglycerol
sequential bi-bi reaction: CDPdiacylglycerol synthase binds to CTP prior to phosphatidate and diphosphate is released prior to CDPdiacylglycerol in the reaction sequence
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CTP + phosphatidate = diphosphate + CDP-diacylglycerol
sequential bi bi reaction mechanism
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CTP + phosphatidate = diphosphate + CDP-diacylglycerol
sequential ordered reaction mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
CTP:phosphatidate cytidylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9067-83-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + 1,2-diarachidonoyl phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
-
-
-
-
?
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
CTP + 1,2-dicaproyl phosphatidic acid
diphosphate + CDP-1,2-dicaproylglycerol
-
-
-
-
?
CTP + 1,2-dioleoyl-sn-glycerol 3-phosphate
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-diolinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diolinoleoylglycerol
-
-
-
?
CTP + 1,2-distearoyl phosphatidic acid
diphosphate + CDP-1,2-distearoylglycerol
-
-
-
-
?
CTP + 1-arachidonoyl-2-stearoyl phosphatidic acid
diphosphate + CDP-1-arachidonoyl-2-stearoylglycerol
-
-
-
-
?
CTP + 1-oleoyl-2-palmitoyl phosphatidic acid
diphosphate + CDP-1-oleoyl-2-palmitoylglycerol
-
reaction with 1-oleoyl-2-palmitoyl phosphatidic acid at 83.4% of the activity with phosphatidic acid from egg phosphatidylcholine
-
-
?
CTP + 1-oleoyl-2-stearoyl phosphatidic acid
diphosphate + CDP-1-oleoyl-2-stearoylglycerol
-
-
-
-
?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
CTP + 1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphate
diphosphate + CDP-1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]glycerol
i.e. commercial substrate NBD-PA
-
-
?
CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoyl-glycerol
-
-
-
?
CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-docosahexaenoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-docosahexaenoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoyl-glycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
CTP + 1-stearoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
-
-
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
-
-
-
?
CTP + 1,2-diarachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-diarachidonoylglycerol
50% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1,2-dilinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dilinoleoylglycerol
-
-
-
?
CTP + 1,2-dilinoleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dilinoleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1,2-dioleoyl phosphatidic acid
diphosphate + CDP-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl phosphatidic acid
diphosphate + CDP-dioleoylglycerol
-
reaction with 1-oleoyl-2-palmitoyl-phosphatidic acid at 87.5% of the activity with phosphatidic acid from egg phosphatidylcholine
-
-
?
CTP + 1,2-dioleoyl phosphatidic acid
diphosphate + CDP-dioleoylglycerol
-
-
-
-
?
CTP + 1,2-dioleoyl-sn-glycero-3-phosphate
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl-sn-glycero-3-phosphate
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dioleoylglycerol
-
-
-
?
CTP + 1,2-dioleoyl-sn-phosphatidic acid
diphosphate + CDP-1,2-dioleoylglycerol
less than 5% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
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?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
best substrate
-
-
?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
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-
-
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?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
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reaction with 1-oleoyl-2-palmitoyl phosphatidic acid at 4.6% of the activity with phosphatidic acid from egg phosphatidylcholine
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?
CTP + 1,2-dipalmitoyl phosphatidic acid
diphosphate + CDP-dipalmitoylglycerol
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-
-
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?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
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-
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?
CTP + 1-palmitoyl-2-arachidonoyl-sn-phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-arachidonoylglycerol
65% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
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?
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
best substrate
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?
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
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reaction with 1-oleoyl-2-palmitoyl phosphatidic acid at 99.7% of the activity with phosphatidic acid from egg phosphatidylcholine
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?
CTP + 1-palmitoyl-2-oleoyl phosphatidic acid
diphosphate + CDP-1-palmitoyl-2-oleoylglycerol
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-
-
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?
CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
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-
-
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?
CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
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-
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?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-linoleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
-
-
-
?
CTP + 1-stearoyl-2-oleoyl-sn-phosphatidic acid
diphosphate + CDP-1-stearoyl-2-oleoylglycerol
20% of the activity with 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
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?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
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-
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?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
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involved in phospholipid synthesis
-
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?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
Bacillus subtilis Marburg / DSM 10 / ATCC 6051
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-
-
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?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
Bacillus subtilis Marburg / DSM 10 / ATCC 6051
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involved in phospholipid synthesis
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-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS1 shows no particular substrate specificity, displaying similar activities for almost all substrates tested
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
isozyme CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
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involved in the de novo biosynthesis of cardiolipin
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-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
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involved in the de novo biosynthesis of cardiolipin
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-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
NBD-phosphatidate
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
r
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
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r
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
phosphatidic acid from egg lecithin and 1-stearoyl 2-arachidonoyl phosphatidic acid are preferred substrates for the microsomal enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Drosophila sp. (in: flies)
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Drosophila sp. (in: flies)
-
the enzyme is required for the regeneration of the signalling molecule phosphatidylinositol-4,5-diphosphate from phosphatidic acid. A photoreceptor cell-specific isoform is a key regulator of phototransduction, a G-protein-coupled signalling cascade mediated by phospholipase C
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Drosophila sp. (in: flies)
-
the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme is specific for long-chain phosphatidic acid. 1-Acyl-sn-glycero-3-phosphate is not a substrate and phosphatidic acids with acyl chains shorter than 16 carbons are poor substrates
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
high activity with phosphatidic acid from egg phosphatidylcholine
-
-
r
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
strong preference for phosphatidic acid with 16-carbon and 18-carbon length fatty acids and at least one unsaturated fatty acid
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
equilibrium constant is 0.22
-
-
r
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme is involved in the regulation of phospholipid metabolism
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the activity is essential for all phospholipid biosynthesis in Escherichia coli
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
the enzyme produces key intermediates in phospholipid biosynthesis
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
didecanoyl phosphatidic acid is the most active of the synthetic phosphatidic acids tested, lysophosphatidic acid is a poor substrate
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Micrococcus cerificans
-
highly specific for CTP
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
Micrococcus cerificans
-
enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
-
-
-
?
CTP + phosphatidate
diphosphate + CDPdiacylglycerol
-
reaction with 1,2-dioleoylphosphatidic acid. Varying the fatty acid composition in the phosphatidic acids added exogenously gives the following order of decreasing activity: 1-stearoyl-2-oleoylphosphatidic acid, 1-oleoyl-2-stearoylphosphatidic acid, 1,2-dioleoylphosphatidic acid, 1-palmitoyl-2-oleoylphosphatidic acid, 1-stearoyl-2-arachidonoylphosphatidic acid, 1-arachidonoyl-2-stearoylphosphatidic acid, 1,2-diarachidonoylphosphatidic acid, 1,2-dicaproylphosphatidic acid, 1,2-dipalmitoylphosphatidic acid, 1,2-distearoylphosphatidic acid
-
-
?