2.7.7.41	CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid	-	
2.7.7.41	CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid	-	
2.7.7.41	CTP + phosphatidate	-	
2.7.7.41	CTP + phosphatidate	the enzyme is involved in the regulation of phospholipid metabolism	
2.7.7.41	CTP + phosphatidate	mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme	
2.7.7.41	CTP + phosphatidate	enzyme plays a central role in phospholipid biosynthesis	
2.7.7.41	CTP + phosphatidate	the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids	
2.7.7.41	CTP + phosphatidate	the enzyme is required for the regeneration of the signalling molecule phosphatidylinositol-4,5-diphosphate from phosphatidic acid. A photoreceptor cell-specific isoform is a key regulator of phototransduction, a G-protein-coupled signalling cascade mediated by phospholipase C	
2.7.7.41	CTP + phosphatidate	the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate	
2.7.7.41	CTP + phosphatidate	regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity	
2.7.7.41	CTP + phosphatidate	the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis	
2.7.7.41	CTP + phosphatidate	enzyme is involved in synthesis of CDP-diglyceride, which plays a primary role in bacterial biosyntheses of essential phosphoglycerides	
2.7.7.41	CTP + phosphatidate	the activity is essential for all phospholipid biosynthesis in Escherichia coli	
2.7.7.41	CTP + phosphatidate	the enzyme produces key intermediates in phospholipid biosynthesis	
2.7.7.41	CTP + phosphatidate	involved in phospholipid synthesis	
2.7.7.41	CTP + phosphatidate	involved in the de novo biosynthesis of cardiolipin	
2.7.7.41	CTP + phosphatidate	involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways	
2.7.7.41	CTP + phosphatidate	isozyme CDS1 shows no particular substrate specificity, displaying similar activities for almost all substrates tested	
2.7.7.41	CTP + phosphatidate	isozyme CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid	
2.7.7.41	dCTP + phosphatidate	mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme	
2.7.7.41	diphosphate + CDP-diacylglycerol	-