EC Number   |
Natural Substrates |
|---|
    2.4.2.28 | more |
metabolic pathway, overview |
| 2.4.2.28 | more |
many malignant cells lack MTAP activity because of chromosomal loss or epigeneticregulation |
| 2.4.2.28 | more |
principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms, intracellular Mtap protein levels determine response to purine biosynthesis inhibitor L-alanosine, overview |
| 2.4.2.28 | S-methyl-5'-thioadenosine + phosphate |
- |
| 2.4.2.28 | S-methyl-5'-thioadenosine + phosphate |
phosphorolysis |
| 2.4.2.28 | S-methyl-5'-thioadenosine + phosphate |
recycling of 5'-methylthioadenosine, the byproduct from spermine and spermidine synthesis, to S-adenosylmethionine, the precursor for polyamine synthesis, pathway overview |
