2.4.2.28	5'-deoxy-5'-(hydroxyethylthio)adenosine + phosphate	trypanocidal substrate analogue	
2.4.2.28	5'-deoxy-5'-(hydroxyethylthio)adenosine + phosphate	preincubation of cells with the substrate lead to 22-37% inhibition of spermidine synthesis from ornithine and 2-7fold increased cytosolic levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine, and up to 8fold increased cytosolic level of 5'-methyladenosine	
2.4.2.28	5'-deoxy-5'-methylthioadenosine + phosphate	salvage reaction	
2.4.2.28	5'-deoxy-5'-methylthioadenosine + phosphate	involved in cardiac purine breakdown during ischemia	
2.4.2.28	5'-deoxy-5'-methylthioadenosine + phosphate	substrate is a by-product of polyamine biosynthesis, which is essential for cell growth and proliferation	
2.4.2.28	5'-deoxy-5'-methylthioadenosine + phosphate	-	
2.4.2.28	5'-methylthioadenosine + phosphate	-	
2.4.2.28	5'-methylthioadenosine + phosphate	important for the salvage of adenine and methionine	
2.4.2.28	5'-methylthioadenosine + phosphate	an antiproliferative effect on stimulated human lymphocytes and virally transformed mouse fibroblasts	
2.4.2.28	5'-methylthioadenosine + phosphate	involved in salvage of adenine and methionine from 5'-methylthioadenosine	
2.4.2.28	5'-methylthioadenosine + phosphate	physiological significance of 5'-methylthioadenosine cleavage is probably related to removal of the thioether which in turn exerts a significant inhibition on methyl transfer reactions	
2.4.2.28	5'-methylthioadenosine + phosphate	the enzyme regulates ornithine decarboxylase by production of downstream metabolites. Tumor suppressor activity of MTAP may be due to its effect on ornithine decarboxylase activity	
2.4.2.28	adenosine + phosphate	-	
2.4.2.28	adenosine + phosphate	the enzyme can use adenosine with the same efficiency as 5'-deoxy-5'-methylthioadenosine	
2.4.2.28	guanosine + phosphate	-	
2.4.2.28	inosine + phosphate	-	
2.4.2.28	additional information	enzyme plays a role in purine and polyamine metabolism and in the regulation of transmethylation reactions	
2.4.2.28	additional information	involved in the catabolism of 5'-methylthioadenosine, adenosine, guanosine and inosine	
2.4.2.28	additional information	inverse correlation between enzyme expression and progression of melanocytic tumors, important role of enzyme inactivation in the development of melanomas	
2.4.2.28	additional information	enzyme is involved in the methionine dependent tumor cell growth	
2.4.2.28	additional information	metabolic pathway, overview	
2.4.2.28	additional information	many malignant cells lack MTAP activity because of chromosomal loss or epigeneticregulation	
2.4.2.28	additional information	principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms, intracellular Mtap protein levels determine response to purine biosynthesis inhibitor L-alanosine, overview	
2.4.2.28	S-methyl-5'-thioadenosine + phosphate	-	
2.4.2.28	S-methyl-5'-thioadenosine + phosphate	phosphorolysis	
2.4.2.28	S-methyl-5'-thioadenosine + phosphate	recycling of 5'-methylthioadenosine, the byproduct from spermine and spermidine synthesis, to S-adenosylmethionine, the precursor for polyamine synthesis, pathway overview