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Results 11 - 20 of 26

EC Number	Natural Substrates	Commentary (Nat. Sub.)
2.4.2.28	5'-methylthioadenosine + phosphate	physiological significance of 5'-methylthioadenosine cleavage is probably related to removal of the thioether which in turn exerts a significant inhibition on methyl transfer reactions
2.4.2.28	5'-methylthioadenosine + phosphate	the enzyme regulates ornithine decarboxylase by production of downstream metabolites. Tumor suppressor activity of MTAP may be due to its effect on ornithine decarboxylase activity
2.4.2.28	adenosine + phosphate	-
2.4.2.28	adenosine + phosphate	the enzyme can use adenosine with the same efficiency as 5'-deoxy-5'-methylthioadenosine
2.4.2.28	guanosine + phosphate	-
2.4.2.28	inosine + phosphate	-
2.4.2.28	more	enzyme plays a role in purine and polyamine metabolism and in the regulation of transmethylation reactions
2.4.2.28	more	involved in the catabolism of 5'-methylthioadenosine, adenosine, guanosine and inosine
2.4.2.28	more	inverse correlation between enzyme expression and progression of melanocytic tumors, important role of enzyme inactivation in the development of melanomas
2.4.2.28	more	enzyme is involved in the methionine dependent tumor cell growth

Results 11 - 20 of 26

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Release 2023.1 (January 2023)