EC Number   |
Natural Substrates |
|---|
    2.3.3.8 | ATP + citrate + CoA |
key enzyme of CO2 fixation by reductive tricarboxylic acid |
| 2.3.3.8 | ATP + citrate + CoA |
one of the key enzymes of lipogenesis |
| 2.3.3.8 | ATP + citrate + CoA |
the enzyme catalyzes the first cytoplasmic step in the synthesis of long-chain fatty acids in mammalian tissues |
| 2.3.3.8 | ATP + citrate + CoA |
the enzyme is responsible for production of cytoplasmic acetyl-CoA for lipogenesis |
| 2.3.3.8 | ATP + citrate + CoA |
key enzyme for lipid accumulation |
| 2.3.3.8 | ATP + citrate + CoA |
acetyl-CoA is produced in mitochondria, but it cannot cross the mitochondrial membranes to the cytosol. Instead, citrate is exported from mitochondria. In the cytosol, ATP-citrate lyase (ACLY; EC 2.3.3.8) catalyses the reaction to produce acetyl-CoA and oxaloacetate from citrate and ATP |
| 2.3.3.8 | ATP + citrate + CoA |
acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (ACL) is utilized to acetylate histone H3 at MyoD regulatory regions, resulting in increased MyoD expression and improved muscle regeneration after injury |
| 2.3.3.8 | ATP + citrate + CoA |
ATP citrate lyase is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis |
| 2.3.3.8 | ATP + citrate + CoA |
essential enzyme for generating acetyl-CoA, a key metabolite for the first step in fatty acid synthesis and for histone acetylation. Regulation of the enzyme activity is a potentially important point of control for cell cycle regulation in the myeloid lineage |
| 2.3.3.8 | ATP + citrate + CoA |
the enzyme catalyzes the formation of cytosolic acetyl CoA, the starting material for de novo lipid and cholesterol biosynthesis |
