EC Number   |
Natural Substrates |
|---|
    2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
the enzyme catalyzes the first committed step in the mevalonate pathway |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
the enzyme is down-regulated by abscisic acid, osmotic stress and dehydration |
| 2.3.3.10 | acetyl-CoA + H2O + acetoacetyl-CoA |
- |
| 2.3.3.10 | acetyl-CoA + H2O + acetoacetyl-CoA |
the enzyme is involved in the mevalonate pathway. Archaea are characterized by cell membrane lipids that contain, as a major component, polyisoprenoids in ether linkages to glycerol rather than the ester-linked fatty acids that characterize membranes of other organisms. Archaeal polyisoprenoids derive from isopentenyl 5-diphosphate produced by enzymes of the mevalonate pathway |
| 2.3.3.10 | acetyl-CoA + H2O + acetoacetyl-CoA |
first committed enzyme in the mevalonate pathway. The enzyme plays an important role in the biosynthesis of the sesquiterpene, which is the main constituent of essential oil in Matricaria chamomilla |
| 2.3.3.10 | acetyl-CoA + H2O + acetoacetyl-CoA |
the enzyme catalyzes a reaction in the mevalonate pathway |
| 2.3.3.10 | acetyl-CoA + H2O + acetoacetyl-CoA |
the enzyme is implicated in latex metabolism |
| 2.3.3.10 | more |
enzyme activity and mRNA levels are upregulated after 3-thia fatty acid treatment |
| 2.3.3.10 | more |
hydroxymethylglutaryl-CoA synthase is involved in an alternative pathway for isovaleryl-coA synthesis |
| 2.3.3.10 | more |
the natural variant (V227A) of peroxisome proliferator-activated receptor-alpha (PPARalpha) significantly attenuates PPARalpha-mediated transactivation of the cytochrome P450 4A6 and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) genes in the presence of fibrate ligands |
