2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	-	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	cytosolic synthase catalyzes the second step of cholesterogenesis from acetyl-CoA	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	produces a key intermediate in steroidogenic and ketogenic metabolic pathways	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	isopentenyl diphosphate biosynthesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	mitochondrial enzyme is involved in the synthesis of acetoacetate, cytoplasmic enzyme in that of mevalonate	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	commited step in the pathways for isoprenoid, cholesterol and ketone body production, cytosolic isoform involved in isoprenoid/cholesterol biosynthesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	mitochondrial enzyme of liver functions in ketogenesis, its cytoplasmic counterpart participates in cholesterogenesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	first committed step in isoprenoid biosynthesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	pathway converting acetyl-CoA to ketone bodies	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	synthesis of isoprenes and steroids	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	regulation of isoprenoid synthesis and metabolism	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	enzyme involved in ketone body production, control of hepatic fatty acid oxidation, potential control point for ketogenesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	pathway of ketogenesis in the mitochondria, mevalonate synthesis in the cytoplasm	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	key role in synthesis of various sterols and isoprenoids	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	major cytoplasmic synthase, synthase II is implicated in cholesterol synthesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	acetoacetate biosynthesis, 3-hydroxy-3-methylglutaryl-CoA pathway	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	mevalonate pathway	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	potentially favorable position for the regulation of hepatic ketogenesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	second enzyme in the cytoplasmic mevalonate pathway of isoprenoid biosynthesis	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	the enzyme catalyzes the first committed step in the mevalonate pathway	
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	the enzyme is down-regulated by abscisic acid, osmotic stress and dehydration	
2.3.3.10	acetyl-CoA + H2O + acetoacetyl-CoA	-	
2.3.3.10	acetyl-CoA + H2O + acetoacetyl-CoA	the enzyme is involved in the mevalonate pathway. Archaea are characterized by cell membrane lipids that contain, as a major component, polyisoprenoids in ether linkages to glycerol rather than the ester-linked fatty acids that characterize membranes of other organisms. Archaeal polyisoprenoids derive from isopentenyl 5-diphosphate produced by enzymes of the mevalonate pathway	
2.3.3.10	acetyl-CoA + H2O + acetoacetyl-CoA	first committed enzyme in the mevalonate pathway. The enzyme plays an important role in the biosynthesis of the sesquiterpene, which is the main constituent of essential oil in Matricaria chamomilla	
2.3.3.10	acetyl-CoA + H2O + acetoacetyl-CoA	the enzyme catalyzes a reaction in the mevalonate pathway	
2.3.3.10	acetyl-CoA + H2O + acetoacetyl-CoA	the enzyme is implicated in latex metabolism	
2.3.3.10	additional information	enzyme activity and mRNA levels are upregulated after 3-thia fatty acid treatment	
2.3.3.10	additional information	hydroxymethylglutaryl-CoA synthase is involved in an alternative pathway for isovaleryl-coA synthesis	
2.3.3.10	additional information	the natural variant (V227A) of peroxisome proliferator-activated receptor-alpha (PPARalpha) significantly attenuates PPARalpha-mediated transactivation of the cytochrome P450 4A6 and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) genes in the presence of fibrate ligands